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• W2001073993 abstract "The actions and the presence of adrenomedullin (AM) were investigated in cultured human oligodendroglial cell line KG1C. AM and AM mRNA were detected in KG1C cells by immunohistochemistry and RT-PCR. mRNAs for calcitonin receptor-like receptor (CRLR) and receptor-activity-modifying proteins (RAMPs) 1, 2 and 3 but not for calcitonin receptors were detected in the cells, while mRNAs for CRLR, calcitonin receptors and all RAMPs were detected in the human cerebellum. Application of AM resulted in time- and concentration-dependent increases in the cAMP level of KG1C cells. Calcitonin gene-related peptide (CGRP) and amylin, peptides structurally related to AM, also increased cAMP. The potencies for the cAMP production of the three peptides were CGRP≥AM≫amylin with EC50 of 8, 18, 90 nM, respectively. The responses induced by AM were strongly inhibited by the CGRP1 receptor antagonist human CGRP8-37, and inhibited also by the AM receptor antagonist human AM22-52. In contrast, the responses induced by CGRP or amylin were inhibited only by CGRP8-37 and not by AM22-52. The responses induced by all three peptides were unaffected by the amylin receptor antagonist human amylin8-37. The CGRP2 receptor agonist human [Cys(Acm)2,7]CGRP significantly increased the cAMP level but the increase was smaller than that caused by CGRP. This increase in cAMP was unaffected by CGRP8-37, AM22-52 or by amylin8-37. These results suggest that in KG1C cells, AM increases cAMP through AM and CGRP1 receptors, whereas CGRP does so through CGRP1 and CGRP2 receptors, and amylin exerts its effects through CGRP1 receptors. Collectively, these findings imply that AM released from oligodendroglial cells may play a role in the regulation of oligodendrocytes via autocrine/paracrine through AM receptors and CGRP1 receptors." @default.
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• W2001073993 date "2001-12-01" @default.
• W2001073993 modified "2023-09-27" @default.
• W2001073993 title "Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C: comparison with calcitonin gene-related peptide and amylin" @default.
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• W2001073993 doi "https://doi.org/10.1016/s0169-328x(01)00288-1" @default.
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