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• W2001085103 startingPage "1496" @default.
• W2001085103 abstract "Rat pituitary cell aggregates cultured in serumfree chemically defined medium, single cells, and hemipituitaries were used in a perifusion system to study the influence of angiotensin II (All) on GH release. In aggregates the peptide displayed both stimulatory and inhibitory effects on GH release, depending on the hormonal conditions of the culture medium and the age of the animal. When cultured in the absence of glucocorticoid, a modest but statistically significant stimulation was seen in aggregates from immature as well as adult animals. In aggregates from 5-day-old animals, dexamethasone (DEX) strongly enhanced the GH-releasing activity of All in a dosedependent way; in aggregates from 14- and 25-day-old rats, the same pattern was found, although the stimulatory action was weaker than the effect in 5-day-old rats. In aggregates from adult animals, the glucocorticoid established an inhibitory effect of All on GH release, an effect seen with both low and high concentrations of DEX. These age- and DEX-dependent effects were not found for All stimulation of PRL release. In the presence of DEX, All also inhibited GRF-induced GH release in aggregates from adult animals, while it was synergistic with GRF in aggregates from developing animals. The effects of All on GH release disappeared when aggregates were redispersed into single cells. However, in these single cell preparations All strongly stimulated PRL release. In hemipituitaries from 1-, 5-, and 14-day-old animals, All also stimulated GH release, but no effect was seen in hemipituitaries from 25-day-old and adult animals. These data indicate that All has dual effects on GH release depending on the developmental stage of the animal and the hormonal environment. Furthermore, since no effect of All was seen after redispersion of aggregates into single cells, both stimulatory and inhibitory effects seem to be based on an intercellular signaling system. (Endocrinology122: 1496–1504, 1988)" @default.
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• W2001085103 date "1988-04-01" @default.
• W2001085103 modified "2023-10-15" @default.
• W2001085103 title "Stimulation and Inhibition of Pituitary Growth Hormone Release by Angiotensin II<i>in Vitro</i>*" @default.
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• W2001085103 doi "https://doi.org/10.1210/endo-122-4-1496" @default.
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