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- W2001085246 abstract "Abstract Objective —To determine the effects of meloxicam and butorphanol on minimum alveolar concentration of isoflurane (MAC ISO ) in rabbits. Animals —10 healthy young adult female rabbits. Procedure —Rabbits were anesthetized with isoflurane on 3 occasions in a blinded, randomized complete block design to determine the MAC ISO associated with administration of meloxicam (0, 0.3, or 1.5 mg/kg, PO) and butorphanol (0.4 mg/kg, IV). The MAC ISO was determined by use of a paw clamp technique as the end-tidal concentration of isoflurane halfway between the values that allowed or inhibited purposeful movement. Rectal temperature, end-tidal CO 2 concentration, heart rate, oxygen saturation, and arterial blood pressure were measured to evaluate cardiopulmonary function. Results —Mean ± SE MAC ISO in saline (0.9% NaCl) solution–treated rabbits was 2.49 ± 0.07% and was not significantly different from that associated with administration of meloxicam at 0.3 mg/kg (2.56 ± 0.07%) or 1.5 mg/kg (2.66 ± 0.07%). Butorphanol significantly reduced the MAC ISO to 2.30 ± 0.07% when administered with saline solution alone, 2.27 ± 0.07% when administered with 0.3 mg of meloxicam/kg, and 2.33 ± 0.07% when administered with 1.5 mg of meloxicam/kg. The percentage reduction in MAC ISO was significantly greater for rabbits that received butorphanol and meloxicam at either dose, compared with butorphanol and saline solution. Conclusions and Clinical Relevance —Results indicated that meloxicam does not have a direct isoflurane-sparing effect and does not interfere with the anesthetic-sparing effect of butorphanol in rabbits." @default.
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- W2001085246 date "2006-05-01" @default.
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- W2001085246 title "Effect of meloxicam and butorphanol on minimum alveolar concentration of isoflurane in rabbits" @default.
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- W2001085246 doi "https://doi.org/10.2460/ajvr.67.5.770" @default.
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