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- W2001088234 abstract "Metabolic engineering uses genetic approaches to control microbial metabolism to produce desired compounds. Computational tools can identify new biological routes to chemicals and the changes needed in host metabolism to improve chemical production. Recent computational efforts have focused on exploring what compounds can be made biologically using native, heterologous, and/or enzymes with broad specificity. Additionally, computational methods have been developed to suggest different types of genetic modifications (e.g. gene deletion/addition or up/down regulation), as well as suggest strategies meeting different criteria (e.g. high yield, high productivity, or substrate co-utilization). Strategies to improve the runtime performances have also been developed, which allow for more complex metabolic engineering strategies to be identified. Future incorporation of kinetic considerations will further improve strain design algorithms." @default.
- W2001088234 created "2016-06-24" @default.
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- W2001088234 date "2015-08-01" @default.
- W2001088234 modified "2023-10-18" @default.
- W2001088234 title "Computational methods in metabolic engineering for strain design" @default.
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- W2001088234 doi "https://doi.org/10.1016/j.copbio.2014.12.019" @default.
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