Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001093821> ?p ?o ?g. }
- W2001093821 endingPage "91" @default.
- W2001093821 startingPage "81" @default.
- W2001093821 abstract "Monoamine-activated human alpha2-macroglobulin (alpha2M) has been previously demonstrated to inhibit TrkA-, TrkB-, and TrkC-mediated signal transduction. Rat alpha1-macroglobulin (alpha1M) and alpha2M are structural homologues of human alpha2M, but rat alpha1M is distinctly different from rat alpha2M in many ways and its role in the mammalian nervous system is unknown. In this report, monoamine-activated rat alpha1M was demonstrated to enhance in a dose-dependent manner nerve growth factor (NGF)-promoted neurite outgrowth in pheochromocytoma PC12 cells. Monoamine-activated alpha1M by itself, however, was neither neurotrophic nor mitogenic to PC12 cells. To investigate further its possible mode of action, the ability of monoamine-activated alpha1M and normal alpha1M to bind and to activate the NGF receptor (TrkA) was investigated. Monoamine-activated alpha1M formed a more stable complex with TrkA than normal alpha1 M, but the binding of monoamine-activated alpha1M to TrkA was adversely affected by prior stimulation of TrkA with NGF. In addition, monoamine-activated alpha1M enhanced the NGF-promoted TrkA phosphorylation and up-regulated the expression of NGF-inducible immediate-early genes (c-jun and NGFI-A) and delayed-response genes (SCG10 and transin) in PC12 cells; normal alpha1M, in contrast, produced little or no effect. This study demonstrates that alpha1M, the constitutive form of alpha-macroglobulin in the rat, possesses the ability to promote NGF-mediated differentiation in PC12 cells, possibly via its direct action on TrkA receptors and TrkA-mediated signal transduction and gene expression." @default.
- W2001093821 created "2016-06-24" @default.
- W2001093821 creator A5011232953 @default.
- W2001093821 creator A5041103765 @default.
- W2001093821 date "2001-12-25" @default.
- W2001093821 modified "2023-10-10" @default.
- W2001093821 title "Rat α1-Macroglobulin Enhances Nerve Growth Factor-Promoted Neurite Outgrowth, TrkA Phosphorylation, and Gene Expression of Pheochromocytoma PC12 Cells" @default.
- W2001093821 cites W1000196571 @default.
- W2001093821 cites W1482124411 @default.
- W2001093821 cites W1512083342 @default.
- W2001093821 cites W1516235379 @default.
- W2001093821 cites W1532766863 @default.
- W2001093821 cites W1555380614 @default.
- W2001093821 cites W1576487122 @default.
- W2001093821 cites W1577472511 @default.
- W2001093821 cites W1582530932 @default.
- W2001093821 cites W1587914632 @default.
- W2001093821 cites W1605704996 @default.
- W2001093821 cites W1618608923 @default.
- W2001093821 cites W1679919731 @default.
- W2001093821 cites W1821277660 @default.
- W2001093821 cites W1857652952 @default.
- W2001093821 cites W1913583396 @default.
- W2001093821 cites W1964106224 @default.
- W2001093821 cites W1970587959 @default.
- W2001093821 cites W1971119534 @default.
- W2001093821 cites W1973216353 @default.
- W2001093821 cites W1974500370 @default.
- W2001093821 cites W1975158306 @default.
- W2001093821 cites W1977311938 @default.
- W2001093821 cites W1977472414 @default.
- W2001093821 cites W1979829646 @default.
- W2001093821 cites W1983828513 @default.
- W2001093821 cites W1984767179 @default.
- W2001093821 cites W1985431192 @default.
- W2001093821 cites W1988840703 @default.
- W2001093821 cites W1990073151 @default.
- W2001093821 cites W1991700287 @default.
- W2001093821 cites W1992281627 @default.
- W2001093821 cites W1992623778 @default.
- W2001093821 cites W1994440513 @default.
- W2001093821 cites W1994721743 @default.
- W2001093821 cites W1996085690 @default.
- W2001093821 cites W2000359435 @default.
- W2001093821 cites W2004820401 @default.
- W2001093821 cites W2008185288 @default.
- W2001093821 cites W2014340217 @default.
- W2001093821 cites W2020333978 @default.
- W2001093821 cites W2021186252 @default.
- W2001093821 cites W2027399729 @default.
- W2001093821 cites W2030473421 @default.
- W2001093821 cites W2030920649 @default.
- W2001093821 cites W2032304318 @default.
- W2001093821 cites W2037831105 @default.
- W2001093821 cites W2043554424 @default.
- W2001093821 cites W2044914819 @default.
- W2001093821 cites W2052537645 @default.
- W2001093821 cites W2055149392 @default.
- W2001093821 cites W2057310742 @default.
- W2001093821 cites W2059648244 @default.
- W2001093821 cites W2063695629 @default.
- W2001093821 cites W2064233821 @default.
- W2001093821 cites W2067880933 @default.
- W2001093821 cites W2068892122 @default.
- W2001093821 cites W2078146089 @default.
- W2001093821 cites W2086275795 @default.
- W2001093821 cites W2088594573 @default.
- W2001093821 cites W2090537556 @default.
- W2001093821 cites W2090896147 @default.
- W2001093821 cites W2092526636 @default.
- W2001093821 cites W2114381143 @default.
- W2001093821 cites W2117512448 @default.
- W2001093821 cites W2125403403 @default.
- W2001093821 cites W2125748383 @default.
- W2001093821 cites W2144263195 @default.
- W2001093821 cites W2146510550 @default.
- W2001093821 cites W2164658118 @default.
- W2001093821 cites W2477054201 @default.
- W2001093821 cites W313034037 @default.
- W2001093821 cites W4248500765 @default.
- W2001093821 cites W4294216491 @default.
- W2001093821 doi "https://doi.org/10.1046/j.1471-4159.2000.0740081.x" @default.
- W2001093821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10617108" @default.
- W2001093821 hasPublicationYear "2001" @default.
- W2001093821 type Work @default.
- W2001093821 sameAs 2001093821 @default.
- W2001093821 citedByCount "10" @default.
- W2001093821 countsByYear W20010938212017 @default.
- W2001093821 crossrefType "journal-article" @default.
- W2001093821 hasAuthorship W2001093821A5011232953 @default.
- W2001093821 hasAuthorship W2001093821A5041103765 @default.
- W2001093821 hasConcept C113246987 @default.
- W2001093821 hasConcept C126322002 @default.
- W2001093821 hasConcept C134018914 @default.
- W2001093821 hasConcept C134139212 @default.
- W2001093821 hasConcept C160539049 @default.
- W2001093821 hasConcept C170493617 @default.
- W2001093821 hasConcept C171034665 @default.