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• W2001096227 abstract "Image scanning a region repeatedly is a burden financially for patients and in labor for staff. Imaging powerful enough to get information for different applications in 1 scan is a current goal. FDG PET provides glucose metabolism imaging and has been widely used in tumor diagnosis and staging. We explored whether FDG PET imaging can serve as a provisional alternative for Tc-99m MAA SPECT for pulmonary perfusion imaging during radiotherapy (RT) for non-small cell lung cancer (NSCLC). Thirty-seven stage I-III NSCLC patients were eligible for this prospective study and treated with a definitive course of conventionally fractionated conformal RT to more than 60 Gy, with concurrent chemotherapy depending on stage of disease. FDG PET/CT and Tc-99m MAA perfusion SPECT/CT were performed 1 month into RT and analyzed by a functional imaging analysis system (FIAT). 1 cm dilated whole lung was considered the volume of interest (VOI) in registration. FDG PET and Q SPECT were registered to each other based on their own CT registration parameters. Whole lung (gross tumor volume excluded) with 1 cm erosion was used as the VOI for correlation analysis. This VOI was split into 10 equal parts from low to high pixel intensity according to the Q SPECT. The split VOIs were applied to FDG PET. The mean value of pixel intensity in each split VOI was tabulated. The top five parts were defined Functional Lung (FL) and the bottom five were defined Defective Lung (DF). The association of pulmonary FDG PET and Q SPECT among split VOIs was evaluated for each patient individually and the mean value of FDG PET and Q SPECT in FL and DF was compared by Pearson correlation and linear correlation. In whole lung analysis, pulmonary FDG PET correlated with Q SPECT in 92% (34/37) of patients, 43% (16/37) of them positive correlation and 49%(18/37) of them negative correlation. Correlations in both groups presented in non-uniform strength. Mean pixel value of FDG PET in functional lung defined by Q SPECT correlated with perfusion (R2 = 0.79 linear correlation; Pearson correlation = 0.91, p = 0.00). In Q SPECT-defined defective lung, mean value FDG PET showed weak correlation with perfusion. (R2 = 0.13 linear correlation; Pearson correlation = 0.36, p = 0.03). Based on supplemental observations, there may be a positive correlation between FDG PET and perfusion in emphysema induced defective lung, and a negative correlation in tumor adjacent, inflammation or radiation damage induced defective lung. In cases of interstitial disease FDG PET-perfusion correlation is complicated. In the functional lung, FDG PET may be a potential proxy for perfusion imaging in patients with NSCLC. In defective lung imaging, etiological diagnosis may help to understand the association between FDG PET and perfusion." @default.
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• W2001096227 date "2010-11-01" @default.
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• W2001096227 title "The Correlation of Pulmonary FDG PET and Perfusion SPECT Imaging During Radiotherapy for Non-small Cell Lung Cancer" @default.
• W2001096227 doi "https://doi.org/10.1016/j.ijrobp.2010.07.491" @default.
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