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- W2001097508 abstract "Forskolin is a potent activator of the cyclic AMP‐generating system in many tissues. In dog thyroid slices, the enhancement of cyclic AMP level was rapid, sustained in the presence of forskolin, but easily reversible after its withdrawal. Contrary to TSH, forskolin induced little apparent desensitization. Forskolin potentiated the effects of TSH, PGE 1 and cholera toxin. However, the forskolin‐induced cyclic AMP accumulation was still sensitive to inhibitors of dog thyroid adenylate cyclase such as iodide, norepinephrine and adenosine. As fluoride, but contrary to TSH and PGE 1 , forskolin stimulated adenylate cyclase in a medium where Mg 2+ was replaced by Mn 2+ . This suggests that in thyroid, as in other tissues, forskolin acts beyond the receptor level but, as it potentiates hormone action and does not impair modulation by inhibitors, it may interact with the nucleotide‐binding regulatory proteins. Forskolin mimicked the effect of TSH on iodide organification and secretion." @default.
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- W2001097508 date "1982-12-13" @default.
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- W2001097508 title "Forskolin stimulates adenylate cyclase and idodine metabolism in thyroid" @default.
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- W2001097508 doi "https://doi.org/10.1016/0014-5793(82)81321-5" @default.
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