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• W2001101543 abstract "Background: Among the obstacles to demonstrating efficacy of pharmacological intervention for aphasia is quantifying patients’ responses to treatment in a statistically valid and reliable manner. In many of the review papers on this topic, detailed discussions of various methodological problems are highlighted, with some suggestions on how these shortcomings should be addressed. Given this deep understanding of caveats associated with the experimental design of aphasia pharmacotherapy studies, investigations continue to produce inconsistent results.Aim: In this review paper, we suggest that the inclusion of theory-driven linguistic measures in aphasia pharmacotherapy studies would add an important step toward elucidating precise patterns of improvement in language performance resulting from pharmacotherapeutic intervention.Main Contribution: We provide a brief review of the clinical approaches currently used in pharmacotherapy studies of aphasia, which often lack psycholinguistic grounding. We then present ways in which psycholinguistic models can complement this approach, offering a rationale for task selection, and as a result, lead to a better understanding of treatment effects. We then follow with an example of how such an integrative approach can be implemented in studies targeting stress reduction in people with aphasia, via beta-blocking agents, as a means to augment language performance, using the recently proposed psycholinguistic framework of “linguistic anxiety” as our guideline.Conclusion: We conclude that the incorporation of psycholinguistic models into aphasia pharmacotherapy studies can increase the resolution with which we can identify functional changes." @default.
• W2001101543 created "2016-06-24" @default.
• W2001101543 creator A5010693808 @default.
• W2001101543 creator A5017195350 @default.
• W2001101543 creator A5077050005 @default.
• W2001101543 date "2013-07-26" @default.
• W2001101543 modified "2023-10-16" @default.
• W2001101543 title "Psycholinguistics of aphasia pharmacotherapy: Asking the right questions" @default.
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• W2001101543 doi "https://doi.org/10.1080/02687038.2013.818099" @default.
• W2001101543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3904395" @default.
• W2001101543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24489425" @default.
• W2001101543 hasPublicationYear "2013" @default.
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