FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001107002> ?p ?o ?g. }

• W2001107002 endingPage "9390" @default.
• W2001107002 startingPage "9381" @default.
• W2001107002 abstract "ABSTRACT The immediate-early regulatory protein ICP22 is required for efficient replication of herpes simplex virus type 1 in some cell types (permissive) but not in others (restrictive). In mice infected via the ocular route, the pathogenesis of an ICP22 − virus, 22/n199, was altered relative to that of wild-type virus. Specifically, tear film titers of 22/n199-infected mice were significantly reduced at 3 h postinfection relative to those of mice infected with wild-type virus. Further, 22/n199 virus titers were below the level of detection in trigeminal ganglia (TG) during the first 9 days postinfection. On day 30 postinfection, TG from 22/n199-infected mice contained reduced viral genome loads and exhibited reduced expression of latency-associated transcripts and reduced reactivation efficiency relative to TG from wild-type virus-infected mice. Notably, the first detectable alteration in the pathogenesis of 22/n199 in these tests occurred in the eye prior to the onset of nascent virus production. Thus, ICP22 − virions appeared to be degraded, cleared, or adsorbed more rapidly than wild-type virions, implying potential differences in the composition of the two virion types. Analysis of the protein composition of purified extracellular virions indicated that ICP22 is not a virion component and that 22/n199 virions sediment at a reduced density relative to wild-type virions. Although similar to wild-type virions morphologically, 22/n199 virions contain reduced amounts of two γ 2 late proteins, U S 11 and gC, and increased amounts of two immediate-early proteins, ICP0 and ICP4, as well as protein species not detected in wild-type virions. Although ICP22 − viruses replicate to near-wild-type levels in permissive cells, the virions produced in these cells are biochemically and physically different from wild-type virions. These virion-specific differences in ICP22 − viruses add a new level of complexity to the functional analysis of this immediate-early viral regulatory protein." @default.
• W2001107002 created "2016-06-24" @default.
• W2001107002 creator A5023208747 @default.
• W2001107002 creator A5030330426 @default.
• W2001107002 creator A5039113255 @default.
• W2001107002 creator A5050076296 @default.
• W2001107002 creator A5050251050 @default.
• W2001107002 creator A5060792296 @default.
• W2001107002 creator A5067933844 @default.
• W2001107002 creator A5089781122 @default.
• W2001107002 date "2006-10-01" @default.
• W2001107002 modified "2023-10-18" @default.
• W2001107002 title "ICP22 Is Required for Wild-Type Composition and Infectivity of Herpes Simplex Virus Type 1 Virions" @default.
• W2001107002 cites W1490731141 @default.
• W2001107002 cites W1525201770 @default.
• W2001107002 cites W1527270080 @default.
• W2001107002 cites W1567025402 @default.
• W2001107002 cites W1586413672 @default.
• W2001107002 cites W1588012052 @default.
• W2001107002 cites W1625770513 @default.
• W2001107002 cites W1673901587 @default.
• W2001107002 cites W1747817694 @default.
• W2001107002 cites W1942310387 @default.
• W2001107002 cites W1961266051 @default.
• W2001107002 cites W1964678759 @default.
• W2001107002 cites W1964857093 @default.
• W2001107002 cites W1969631125 @default.
• W2001107002 cites W2031078870 @default.
• W2001107002 cites W2062924063 @default.
• W2001107002 cites W2064479381 @default.
• W2001107002 cites W2071327617 @default.
• W2001107002 cites W2079025991 @default.
• W2001107002 cites W2086996422 @default.
• W2001107002 cites W2094400633 @default.
• W2001107002 cites W2101116346 @default.
• W2001107002 cites W2101202684 @default.
• W2001107002 cites W2106831552 @default.
• W2001107002 cites W2114337771 @default.
• W2001107002 cites W2115374657 @default.
• W2001107002 cites W2116949284 @default.
• W2001107002 cites W2122280181 @default.
• W2001107002 cites W2124912335 @default.
• W2001107002 cites W2132583909 @default.
• W2001107002 cites W2133256374 @default.
• W2001107002 cites W2140541319 @default.
• W2001107002 cites W2140872922 @default.
• W2001107002 cites W2141424564 @default.
• W2001107002 cites W2144378803 @default.
• W2001107002 cites W2149367731 @default.
• W2001107002 cites W2155661903 @default.
• W2001107002 cites W2160076699 @default.
• W2001107002 cites W2164758952 @default.
• W2001107002 cites W2164897233 @default.
• W2001107002 cites W2165589948 @default.
• W2001107002 cites W2171983197 @default.
• W2001107002 cites W2333689301 @default.
• W2001107002 cites W2395750117 @default.
• W2001107002 cites W2467571305 @default.
• W2001107002 doi "https://doi.org/10.1128/jvi.01061-06" @default.
• W2001107002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1617265" @default.
• W2001107002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16973544" @default.
• W2001107002 hasPublicationYear "2006" @default.
• W2001107002 type Work @default.
• W2001107002 sameAs 2001107002 @default.
• W2001107002 citedByCount "37" @default.
• W2001107002 countsByYear W20011070022012 @default.
• W2001107002 countsByYear W20011070022013 @default.
• W2001107002 countsByYear W20011070022014 @default.
• W2001107002 countsByYear W20011070022016 @default.
• W2001107002 countsByYear W20011070022017 @default.
• W2001107002 countsByYear W20011070022019 @default.
• W2001107002 countsByYear W20011070022020 @default.
• W2001107002 countsByYear W20011070022022 @default.
• W2001107002 countsByYear W20011070022023 @default.
• W2001107002 crossrefType "journal-article" @default.
• W2001107002 hasAuthorship W2001107002A5023208747 @default.
• W2001107002 hasAuthorship W2001107002A5030330426 @default.
• W2001107002 hasAuthorship W2001107002A5039113255 @default.
• W2001107002 hasAuthorship W2001107002A5050076296 @default.
• W2001107002 hasAuthorship W2001107002A5050251050 @default.
• W2001107002 hasAuthorship W2001107002A5060792296 @default.
• W2001107002 hasAuthorship W2001107002A5067933844 @default.
• W2001107002 hasAuthorship W2001107002A5089781122 @default.
• W2001107002 hasBestOaLocation W20011070021 @default.
• W2001107002 hasConcept C104317684 @default.
• W2001107002 hasConcept C106358424 @default.
• W2001107002 hasConcept C140704245 @default.
• W2001107002 hasConcept C143065580 @default.
• W2001107002 hasConcept C153911025 @default.
• W2001107002 hasConcept C159047783 @default.
• W2001107002 hasConcept C202878990 @default.
• W2001107002 hasConcept C203014093 @default.
• W2001107002 hasConcept C207583985 @default.
• W2001107002 hasConcept C2522874641 @default.
• W2001107002 hasConcept C2780942790 @default.
• W2001107002 hasConcept C2781196997 @default.
• W2001107002 hasConcept C28406088 @default.
• W2001107002 hasConcept C32611913 @default.

• next