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- W2001108312 abstract "A new oral dosage form is described and studied. It consists of dispersing the drug into Gelucire, with an addition of a small amount of a polymer called Sumikagel®. Gelucire plays a role of an erodible polymer matrix with a low rate of erosion. Sumikagel swells to various extents depending on the pH of the liquid in which it is immersed. As a result these new dosage forms disintegrated completely in aqueous solution of pH 8 in less than 1 h, while the rate of drug delivery remained constant during the whole process. The delivery of the drug is successfully described by transient diffusion when the liquid is acid with pH 1.2. A simulation of the gastrointestinal tract is studied by using in-vitro tests, from the experimental and theoretical point of view." @default.
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- W2001108312 date "1991-05-01" @default.
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- W2001108312 title "New oral dosage form with two polymers: Gelucire and Sumikagel" @default.
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- W2001108312 doi "https://doi.org/10.1016/0378-5173(91)90378-2" @default.
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