FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001114848> ?p ?o ?g. }

• W2001114848 endingPage "2055" @default.
• W2001114848 startingPage "2048" @default.
• W2001114848 abstract "KIT and PDGFRA are receptor tyrosine kinases that can be specifically inactivated by small-molecule tyrosine kinase inhibitors, notably imatinib mesylate. In ovarian carcinoma, expression of KIT and PDGFRA protein has been documented, but the frequency and the molecular background of expression are poorly known. We analysed the expression of KIT and PDGFRA by immunohistochemistry in 522 serous ovarian carcinomas, and mutations of KIT and PDGFRA by denaturing high-performance liquid chromatographyin 125 and 187 serous ovarian carcinomas, respectively. No mutations of KIT or PDGFRA were detected. KIT expression was detected in 12% of carcinomas: low expression in 10% and high expression in 2% of cases. Using normal serous epithelium as a reference, decreased PDGFRA expression was detected in 12% and increased expression in 13% of carcinomas. Both KIT and PDGFRA expression were associated with high tumour grade, high proliferation index and poor patient outcome. By fluorescence in situ hybridisation, no KIT amplification was found in carcinomas with high KIT expression, but two cases showed a relative gain of chromosome 4. In conclusion, no mutations of KIT or PDGFRA were found, but a subset of serous ovarian carcinoma showed overexpression of the proteins, which was associated with aggressive tumour characteristics." @default.
• W2001114848 created "2016-06-24" @default.
• W2001114848 creator A5004114938 @default.
• W2001114848 creator A5010863055 @default.
• W2001114848 creator A5013518934 @default.
• W2001114848 creator A5029463204 @default.
• W2001114848 creator A5045698969 @default.
• W2001114848 creator A5071495735 @default.
• W2001114848 creator A5090618504 @default.
• W2001114848 date "2004-12-01" @default.
• W2001114848 modified "2023-10-13" @default.
• W2001114848 title "Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma" @default.
• W2001114848 cites W1505255521 @default.
• W2001114848 cites W1522716655 @default.
• W2001114848 cites W1544533071 @default.
• W2001114848 cites W1578826342 @default.
• W2001114848 cites W1787878270 @default.
• W2001114848 cites W1970079579 @default.
• W2001114848 cites W1978082129 @default.
• W2001114848 cites W1992031785 @default.
• W2001114848 cites W2007194438 @default.
• W2001114848 cites W2008920989 @default.
• W2001114848 cites W2010500685 @default.
• W2001114848 cites W2015015957 @default.
• W2001114848 cites W2030057775 @default.
• W2001114848 cites W2031209812 @default.
• W2001114848 cites W2034455009 @default.
• W2001114848 cites W2038596108 @default.
• W2001114848 cites W2043696829 @default.
• W2001114848 cites W2044829318 @default.
• W2001114848 cites W2085000900 @default.
• W2001114848 cites W2087810003 @default.
• W2001114848 cites W2091394697 @default.
• W2001114848 cites W2102820425 @default.
• W2001114848 cites W2107813887 @default.
• W2001114848 cites W2115759102 @default.
• W2001114848 cites W2119455657 @default.
• W2001114848 cites W2121341625 @default.
• W2001114848 cites W2125492990 @default.
• W2001114848 cites W2126436436 @default.
• W2001114848 cites W2128818776 @default.
• W2001114848 cites W2150501295 @default.
• W2001114848 cites W2151527507 @default.
• W2001114848 cites W2154804898 @default.
• W2001114848 cites W2159620641 @default.
• W2001114848 cites W2168820857 @default.
• W2001114848 cites W4239989216 @default.
• W2001114848 cites W4241370600 @default.
• W2001114848 doi "https://doi.org/10.1038/sj.bjc.6602252" @default.
• W2001114848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2409787" @default.
• W2001114848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15583695" @default.
• W2001114848 hasPublicationYear "2004" @default.
• W2001114848 type Work @default.
• W2001114848 sameAs 2001114848 @default.
• W2001114848 citedByCount "66" @default.
• W2001114848 countsByYear W20011148482012 @default.
• W2001114848 countsByYear W20011148482013 @default.
• W2001114848 countsByYear W20011148482014 @default.
• W2001114848 countsByYear W20011148482015 @default.
• W2001114848 countsByYear W20011148482016 @default.
• W2001114848 countsByYear W20011148482017 @default.
• W2001114848 countsByYear W20011148482018 @default.
• W2001114848 countsByYear W20011148482021 @default.
• W2001114848 countsByYear W20011148482023 @default.
• W2001114848 crossrefType "journal-article" @default.
• W2001114848 hasAuthorship W2001114848A5004114938 @default.
• W2001114848 hasAuthorship W2001114848A5010863055 @default.
• W2001114848 hasAuthorship W2001114848A5013518934 @default.
• W2001114848 hasAuthorship W2001114848A5029463204 @default.
• W2001114848 hasAuthorship W2001114848A5045698969 @default.
• W2001114848 hasAuthorship W2001114848A5071495735 @default.
• W2001114848 hasAuthorship W2001114848A5090618504 @default.
• W2001114848 hasBestOaLocation W20011148481 @default.
• W2001114848 hasConcept C101544691 @default.
• W2001114848 hasConcept C121608353 @default.
• W2001114848 hasConcept C142724271 @default.
• W2001114848 hasConcept C150173356 @default.
• W2001114848 hasConcept C16930146 @default.
• W2001114848 hasConcept C170493617 @default.
• W2001114848 hasConcept C184235292 @default.
• W2001114848 hasConcept C204232928 @default.
• W2001114848 hasConcept C2775922572 @default.
• W2001114848 hasConcept C2777632260 @default.
• W2001114848 hasConcept C2780427987 @default.
• W2001114848 hasConcept C3019054536 @default.
• W2001114848 hasConcept C37307934 @default.
• W2001114848 hasConcept C42362537 @default.
• W2001114848 hasConcept C502942594 @default.
• W2001114848 hasConcept C54355233 @default.
• W2001114848 hasConcept C71924100 @default.
• W2001114848 hasConcept C86803240 @default.
• W2001114848 hasConceptScore W2001114848C101544691 @default.
• W2001114848 hasConceptScore W2001114848C121608353 @default.
• W2001114848 hasConceptScore W2001114848C142724271 @default.
• W2001114848 hasConceptScore W2001114848C150173356 @default.
• W2001114848 hasConceptScore W2001114848C16930146 @default.
• W2001114848 hasConceptScore W2001114848C170493617 @default.
• W2001114848 hasConceptScore W2001114848C184235292 @default.

• next