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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001125556> ?p ?o ?g. }

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• W2001125556 abstract "G protein-coupled receptor kinases (GRK) have been classically considered as negative regulators of G protein-coupled receptors. However, cumulative evidence is putting forward novel roles for GRKs. These include a positive role in signal transmission based on differential receptor phosphorylation leading to the recruitment of distinct arrestin-orchestrated signalosomes as well as previously unforeseen regulatory functions in cell signaling routes unrelated to this family of seven-transmembrane receptors. These new functions and the targeting strategies available at present to address GRK biology are discussed in this review." @default.
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• W2001125556 date "2010-03-01" @default.
• W2001125556 modified "2023-10-14" @default.
• W2001125556 title "G protein-coupled receptor kinases: Specific phosphorylation of 7TM receptors and beyond" @default.
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• W2001125556 doi "https://doi.org/10.1016/j.ddtec.2010.05.002" @default.
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