Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001133172> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2001133172 endingPage "580" @default.
- W2001133172 startingPage "576" @default.
- W2001133172 abstract "There are contradictory reports regarding the effects of inhalation anesthetics on the immune system. Measurable immune responses have been studied in vitro, but little is known about the in vivo effects in the intact organism. We used an attenuated, non-neuroinvasive, nonlethal strain of the encephalitic West Nile virus, termed WN-25, which can become lethal in combination with environmental stressors, to study possible modulatory immune effects of inhalation anesthetics in mice. Both single short-term exposure and repeated exposure to halothane and nitrous oxide were studied. Exposure to 30% CO2 served as a positive control. Mortality, brain invasion, spleen weight, and antiviral antibodies served as the experimental endpoints. Halothane and nitrous oxide led to viral brain invasion, increased mortality, and suppressed immune response in a concentration- and time-dependent manner. Repeated exposures had a cumulative effect. Assessment of the stability of the viral attenuation did not demonstrate any alteration in the character of the virus, suggesting an increased access to the brain by inhalation anesthetics that led to the fatal encephalitis. These findings may be of special concern to populations at risk, such as operating room staff and patients undergoing general anesthesia in endemic areas of encephalitic virus species, in which subclinical infection may develop into an overt disease." @default.
- W2001133172 created "2016-06-24" @default.
- W2001133172 creator A5023832302 @default.
- W2001133172 creator A5023893116 @default.
- W2001133172 creator A5027069104 @default.
- W2001133172 creator A5042134707 @default.
- W2001133172 creator A5068016071 @default.
- W2001133172 date "2002-02-05" @default.
- W2001133172 modified "2023-09-24" @default.
- W2001133172 title "Inhalation anesthetic-induced neuroinvasion by an attenuated strain of West Nile virus in mice" @default.
- W2001133172 cites W1488658095 @default.
- W2001133172 cites W1967260317 @default.
- W2001133172 cites W1974735062 @default.
- W2001133172 cites W1980328559 @default.
- W2001133172 cites W1984119541 @default.
- W2001133172 cites W1988058954 @default.
- W2001133172 cites W1990863475 @default.
- W2001133172 cites W1999028283 @default.
- W2001133172 cites W2007660000 @default.
- W2001133172 cites W2014756777 @default.
- W2001133172 cites W2052641241 @default.
- W2001133172 cites W2058623593 @default.
- W2001133172 cites W2070007634 @default.
- W2001133172 cites W2076027261 @default.
- W2001133172 cites W2077273368 @default.
- W2001133172 cites W2082809257 @default.
- W2001133172 cites W2091817754 @default.
- W2001133172 cites W2118911422 @default.
- W2001133172 cites W2141684978 @default.
- W2001133172 cites W2614172160 @default.
- W2001133172 cites W4245171369 @default.
- W2001133172 cites W4246225109 @default.
- W2001133172 doi "https://doi.org/10.1002/jmv.2184" @default.
- W2001133172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11857540" @default.
- W2001133172 hasPublicationYear "2002" @default.
- W2001133172 type Work @default.
- W2001133172 sameAs 2001133172 @default.
- W2001133172 citedByCount "11" @default.
- W2001133172 countsByYear W20011331722013 @default.
- W2001133172 countsByYear W20011331722014 @default.
- W2001133172 countsByYear W20011331722015 @default.
- W2001133172 crossrefType "journal-article" @default.
- W2001133172 hasAuthorship W2001133172A5023832302 @default.
- W2001133172 hasAuthorship W2001133172A5023893116 @default.
- W2001133172 hasAuthorship W2001133172A5027069104 @default.
- W2001133172 hasAuthorship W2001133172A5042134707 @default.
- W2001133172 hasAuthorship W2001133172A5068016071 @default.
- W2001133172 hasConcept C113280763 @default.
- W2001133172 hasConcept C159047783 @default.
- W2001133172 hasConcept C203014093 @default.
- W2001133172 hasConcept C2522874641 @default.
- W2001133172 hasConcept C2776932660 @default.
- W2001133172 hasConcept C2776954882 @default.
- W2001133172 hasConcept C2778116200 @default.
- W2001133172 hasConcept C2778162923 @default.
- W2001133172 hasConcept C42219234 @default.
- W2001133172 hasConcept C71924100 @default.
- W2001133172 hasConcept C83455156 @default.
- W2001133172 hasConcept C86803240 @default.
- W2001133172 hasConcept C8891405 @default.
- W2001133172 hasConceptScore W2001133172C113280763 @default.
- W2001133172 hasConceptScore W2001133172C159047783 @default.
- W2001133172 hasConceptScore W2001133172C203014093 @default.
- W2001133172 hasConceptScore W2001133172C2522874641 @default.
- W2001133172 hasConceptScore W2001133172C2776932660 @default.
- W2001133172 hasConceptScore W2001133172C2776954882 @default.
- W2001133172 hasConceptScore W2001133172C2778116200 @default.
- W2001133172 hasConceptScore W2001133172C2778162923 @default.
- W2001133172 hasConceptScore W2001133172C42219234 @default.
- W2001133172 hasConceptScore W2001133172C71924100 @default.
- W2001133172 hasConceptScore W2001133172C83455156 @default.
- W2001133172 hasConceptScore W2001133172C86803240 @default.
- W2001133172 hasConceptScore W2001133172C8891405 @default.
- W2001133172 hasIssue "4" @default.
- W2001133172 hasLocation W20011331721 @default.
- W2001133172 hasLocation W20011331722 @default.
- W2001133172 hasOpenAccess W2001133172 @default.
- W2001133172 hasPrimaryLocation W20011331721 @default.
- W2001133172 hasRelatedWork W1487857142 @default.
- W2001133172 hasRelatedWork W1949399753 @default.
- W2001133172 hasRelatedWork W2008896678 @default.
- W2001133172 hasRelatedWork W2010455632 @default.
- W2001133172 hasRelatedWork W2038175347 @default.
- W2001133172 hasRelatedWork W2087451743 @default.
- W2001133172 hasRelatedWork W2143486983 @default.
- W2001133172 hasRelatedWork W2403447631 @default.
- W2001133172 hasRelatedWork W1543294417 @default.
- W2001133172 hasRelatedWork W2561842636 @default.
- W2001133172 hasVolume "66" @default.
- W2001133172 isParatext "false" @default.
- W2001133172 isRetracted "false" @default.
- W2001133172 magId "2001133172" @default.
- W2001133172 workType "article" @default.