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- W2001133498 abstract "Condensation of diethyl formylamino- or diethyl acetylaminomalonate with 4-, 5- or 6-nitrogramine 1 afforded the diethyl formylamino- or the diethyl acetylamino[(nitroindol)-3-ylmethyl]malonates 2; reduction of the nitro group followed by N-formylation or acetylation of the resulting amino compounds 3, led to the 4-, 5-and 6-acylamino derivatives 4. Cyclization of 4 in the presence of polyphosphoric esters gave the 3,3-bis(ethoxycarbonyl)-3,4-dihydro-β-carbolines 5, which underwent lithium chloride/water catalyzed monodeethoxycarbonylation to the corresponding 5-, 6- and 7-acylamino-3-ethoxycarbonyl-β-carbolines 6, whose acidic hydrolysis led finally to the 5-, 6- and 7-amino-3-ethoxycarbonyl-β-carbolines 9. The 6-amino compounds 9b-e were obtained also by direct nitration of 3-methoxycarbonyl-β-carboline 7a and of 3-ethoxycarbonyl-β-carboline 7c, followed by the nitro group reduction of the resulting nitro carbolines 8. Preliminary studies of the binding to rabbit brain benzodiazepine receptor sites indicate compounds 9b and 9c to inhibit the 3H-diazepam binding at 10−8 M concentrations." @default.
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- W2001133498 date "1988-09-01" @default.
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- W2001133498 title "β-Carbolines as agonistic or antagonistic benzodiazepine receptor ligands.<b>1</b>. Synthesis of some 5-, 6- and 7-amino derivatives of 3-methoxycarbonyl-β-carboline (β-CCM) and of 3-ethoxycarbonyl-β-carboline (β-CCE)" @default.
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- W2001133498 doi "https://doi.org/10.1002/jhet.5570250524" @default.
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