FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001138503> ?p ?o ?g. }

• W2001138503 endingPage "271" @default.
• W2001138503 startingPage "262" @default.
• W2001138503 abstract "Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a novel IL-21 isoform named IL-21iso. In this study, we found that in addition to the conventional IL-21, IL-21iso mRNA was also expressed in the colon with DSS-induced colitis. To investigate whether IL-21iso plays a role in DSS-induced colitis, we established transgenic mice (mIL-21iso-Tg mice) that expressed mouse IL-21iso under the control of the lck proximal promoter. Although mIL-21iso-Tg mice did not have any gross physical abnormalities, their peripheral lymphocytes counts were higher than those in wild-type littermates. Notably, their CD8(+) T cell and CD4(+) effector memory T-cell populations were elevated. DSS-induced colitis was far more severe in the mIL-21iso-Tg mice than in wild-type mice, and was accompanied by a marked loss of body weight and by colon inflammation with increased cellular infiltration. In DSS-treated mice, colon tissues from mIL-21iso-Tg mice had significantly higher gene activation levels for cytokines such as IL-17A, TNF-α, IL-6, IL-10, and IL-4, and for transcription factors such as T-bet, GATA-3, RORγt, and Foxp3, than were found in wild-type mice. These results indicate that besides IL-21, IL-21iso may be another regulator of gut inflammation." @default.
• W2001138503 created "2016-06-24" @default.
• W2001138503 creator A5009986846 @default.
• W2001138503 creator A5014672643 @default.
• W2001138503 creator A5015722622 @default.
• W2001138503 creator A5017851024 @default.
• W2001138503 creator A5027835055 @default.
• W2001138503 creator A5033734660 @default.
• W2001138503 creator A5036122583 @default.
• W2001138503 creator A5041660529 @default.
• W2001138503 creator A5061980173 @default.
• W2001138503 creator A5089729896 @default.
• W2001138503 date "2013-05-01" @default.
• W2001138503 modified "2023-09-25" @default.
• W2001138503 title "Role of interleukin-21 isoform in dextran sulfate sodium (DSS)-induced colitis" @default.
• W2001138503 cites W1518281728 @default.
• W2001138503 cites W1967800669 @default.
• W2001138503 cites W1967949491 @default.
• W2001138503 cites W1974612446 @default.
• W2001138503 cites W1979791017 @default.
• W2001138503 cites W1985577573 @default.
• W2001138503 cites W1985669208 @default.
• W2001138503 cites W1992465269 @default.
• W2001138503 cites W2004083136 @default.
• W2001138503 cites W2009783794 @default.
• W2001138503 cites W2018478222 @default.
• W2001138503 cites W2020420876 @default.
• W2001138503 cites W2022606300 @default.
• W2001138503 cites W2024368831 @default.
• W2001138503 cites W2024490058 @default.
• W2001138503 cites W2029581491 @default.
• W2001138503 cites W2031737767 @default.
• W2001138503 cites W2033695771 @default.
• W2001138503 cites W2042183983 @default.
• W2001138503 cites W2046491426 @default.
• W2001138503 cites W2049867169 @default.
• W2001138503 cites W2066497132 @default.
• W2001138503 cites W2085587260 @default.
• W2001138503 cites W2094771034 @default.
• W2001138503 cites W2095792567 @default.
• W2001138503 cites W2096459892 @default.
• W2001138503 cites W2098226124 @default.
• W2001138503 cites W2102364213 @default.
• W2001138503 cites W2114439941 @default.
• W2001138503 cites W2138483765 @default.
• W2001138503 cites W2139869391 @default.
• W2001138503 cites W2153268818 @default.
• W2001138503 cites W2154740756 @default.
• W2001138503 cites W2162493503 @default.
• W2001138503 cites W2163518962 @default.
• W2001138503 cites W2163828646 @default.
• W2001138503 cites W2170083578 @default.
• W2001138503 doi "https://doi.org/10.1016/j.cyto.2013.03.006" @default.
• W2001138503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23557800" @default.
• W2001138503 hasPublicationYear "2013" @default.
• W2001138503 type Work @default.
• W2001138503 sameAs 2001138503 @default.
• W2001138503 citedByCount "17" @default.
• W2001138503 countsByYear W20011385032014 @default.
• W2001138503 countsByYear W20011385032015 @default.
• W2001138503 countsByYear W20011385032016 @default.
• W2001138503 countsByYear W20011385032017 @default.
• W2001138503 countsByYear W20011385032018 @default.
• W2001138503 countsByYear W20011385032019 @default.
• W2001138503 countsByYear W20011385032020 @default.
• W2001138503 countsByYear W20011385032021 @default.
• W2001138503 crossrefType "journal-article" @default.
• W2001138503 hasAuthorship W2001138503A5009986846 @default.
• W2001138503 hasAuthorship W2001138503A5014672643 @default.
• W2001138503 hasAuthorship W2001138503A5015722622 @default.
• W2001138503 hasAuthorship W2001138503A5017851024 @default.
• W2001138503 hasAuthorship W2001138503A5027835055 @default.
• W2001138503 hasAuthorship W2001138503A5033734660 @default.
• W2001138503 hasAuthorship W2001138503A5036122583 @default.
• W2001138503 hasAuthorship W2001138503A5041660529 @default.
• W2001138503 hasAuthorship W2001138503A5061980173 @default.
• W2001138503 hasAuthorship W2001138503A5089729896 @default.
• W2001138503 hasConcept C102230213 @default.
• W2001138503 hasConcept C104317684 @default.
• W2001138503 hasConcept C126322002 @default.
• W2001138503 hasConcept C141035611 @default.
• W2001138503 hasConcept C167672396 @default.
• W2001138503 hasConcept C185592680 @default.
• W2001138503 hasConcept C203014093 @default.
• W2001138503 hasConcept C2775862500 @default.
• W2001138503 hasConcept C2776914184 @default.
• W2001138503 hasConcept C2778260677 @default.
• W2001138503 hasConcept C2779134260 @default.
• W2001138503 hasConcept C2779727006 @default.
• W2001138503 hasConcept C53345823 @default.
• W2001138503 hasConcept C55493867 @default.
• W2001138503 hasConcept C71924100 @default.
• W2001138503 hasConcept C74737994 @default.
• W2001138503 hasConcept C86803240 @default.
• W2001138503 hasConcept C8891405 @default.
• W2001138503 hasConceptScore W2001138503C102230213 @default.
• W2001138503 hasConceptScore W2001138503C104317684 @default.
• W2001138503 hasConceptScore W2001138503C126322002 @default.

• next