FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001139664> ?p ?o ?g. }

• W2001139664 endingPage "514" @default.
• W2001139664 startingPage "507" @default.
• W2001139664 abstract "Abstract Mannan‐binding lectin (MBL) is a collectin and a major soluble pattern‐recognition protein. MBL can distinguish self from nonself and altered self using its C‐type carbohydrate recognition domain and may also interact via its collagen‐like region with autologous cells. Recently, it was found that MBL could bind to adherent cells (monocytes) and dendritic cells in a specific and sugar‐sensitive manner. We have now investigated the interaction of MBL with fresh human peripheral blood cells and report binding to B lymphocytes and natural killer cells. The binding to B lymphocytes was studied in detail and was compared with the binding of MBL to monocytes and dendritic cells. Binding of MBL to B cells was evident at physiological MBL and calcium concentrations but was optimal at supraphysiological MBL concentrations. It was readily inhibited by autologous serum, mannan, mannose, GlcNAc and (to a lesser extent) galactose but not by C1q. A similar, but not identical, inhibition profile was observed with dendritic cells, but monocytes were not sensitive to mannose or mannan. We conclude that MBL is capable of binding to differently glycosylated ligands on several autologous cell types via its carbohydrate‐recognition domain. We speculate that this could have functional significance at extravascular sites, but perhaps only in individuals possessing MBL genotypes conferring MBL sufficiency." @default.
• W2001139664 created "2016-06-24" @default.
• W2001139664 creator A5019944316 @default.
• W2001139664 creator A5021119669 @default.
• W2001139664 creator A5065560052 @default.
• W2001139664 creator A5075942749 @default.
• W2001139664 date "2005-11-29" @default.
• W2001139664 modified "2023-10-15" @default.
• W2001139664 title "Detection of an Autologous Ligand for Mannan-Binding Lectin on Human B Lymphocytes" @default.
• W2001139664 cites W1965036756 @default.
• W2001139664 cites W1968986552 @default.
• W2001139664 cites W1978567121 @default.
• W2001139664 cites W1979930475 @default.
• W2001139664 cites W1979999043 @default.
• W2001139664 cites W1983791133 @default.
• W2001139664 cites W1988943863 @default.
• W2001139664 cites W1992830524 @default.
• W2001139664 cites W2011712988 @default.
• W2001139664 cites W2015630097 @default.
• W2001139664 cites W2024866939 @default.
• W2001139664 cites W2029612554 @default.
• W2001139664 cites W2033266138 @default.
• W2001139664 cites W2043501640 @default.
• W2001139664 cites W2053863608 @default.
• W2001139664 cites W2064001879 @default.
• W2001139664 cites W2065190979 @default.
• W2001139664 cites W2074548201 @default.
• W2001139664 cites W2074919825 @default.
• W2001139664 cites W2076411129 @default.
• W2001139664 cites W2086535889 @default.
• W2001139664 cites W2126261381 @default.
• W2001139664 cites W2152799956 @default.
• W2001139664 cites W4313316341 @default.
• W2001139664 cites W98982711 @default.
• W2001139664 doi "https://doi.org/10.1111/j.1365-3083.2005.01693.x" @default.
• W2001139664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16316417" @default.
• W2001139664 hasPublicationYear "2005" @default.
• W2001139664 type Work @default.
• W2001139664 sameAs 2001139664 @default.
• W2001139664 citedByCount "21" @default.
• W2001139664 countsByYear W20011396642012 @default.
• W2001139664 countsByYear W20011396642013 @default.
• W2001139664 countsByYear W20011396642015 @default.
• W2001139664 countsByYear W20011396642019 @default.
• W2001139664 countsByYear W20011396642022 @default.
• W2001139664 countsByYear W20011396642023 @default.
• W2001139664 crossrefType "journal-article" @default.
• W2001139664 hasAuthorship W2001139664A5019944316 @default.
• W2001139664 hasAuthorship W2001139664A5021119669 @default.
• W2001139664 hasAuthorship W2001139664A5065560052 @default.
• W2001139664 hasAuthorship W2001139664A5075942749 @default.
• W2001139664 hasConcept C100817775 @default.
• W2001139664 hasConcept C106257327 @default.
• W2001139664 hasConcept C124594742 @default.
• W2001139664 hasConcept C133493029 @default.
• W2001139664 hasConcept C136449434 @default.
• W2001139664 hasConcept C153911025 @default.
• W2001139664 hasConcept C189413060 @default.
• W2001139664 hasConcept C203014093 @default.
• W2001139664 hasConcept C2775887612 @default.
• W2001139664 hasConcept C2779719659 @default.
• W2001139664 hasConcept C2780758401 @default.
• W2001139664 hasConcept C55493867 @default.
• W2001139664 hasConcept C86803240 @default.
• W2001139664 hasConcept C8891405 @default.
• W2001139664 hasConceptScore W2001139664C100817775 @default.
• W2001139664 hasConceptScore W2001139664C106257327 @default.
• W2001139664 hasConceptScore W2001139664C124594742 @default.
• W2001139664 hasConceptScore W2001139664C133493029 @default.
• W2001139664 hasConceptScore W2001139664C136449434 @default.
• W2001139664 hasConceptScore W2001139664C153911025 @default.
• W2001139664 hasConceptScore W2001139664C189413060 @default.
• W2001139664 hasConceptScore W2001139664C203014093 @default.
• W2001139664 hasConceptScore W2001139664C2775887612 @default.
• W2001139664 hasConceptScore W2001139664C2779719659 @default.
• W2001139664 hasConceptScore W2001139664C2780758401 @default.
• W2001139664 hasConceptScore W2001139664C55493867 @default.
• W2001139664 hasConceptScore W2001139664C86803240 @default.
• W2001139664 hasConceptScore W2001139664C8891405 @default.
• W2001139664 hasIssue "6" @default.
• W2001139664 hasLocation W20011396641 @default.
• W2001139664 hasLocation W20011396642 @default.
• W2001139664 hasOpenAccess W2001139664 @default.
• W2001139664 hasPrimaryLocation W20011396641 @default.
• W2001139664 hasRelatedWork W1929312016 @default.
• W2001139664 hasRelatedWork W1966576522 @default.
• W2001139664 hasRelatedWork W2000547049 @default.
• W2001139664 hasRelatedWork W2035470844 @default.
• W2001139664 hasRelatedWork W2065622508 @default.
• W2001139664 hasRelatedWork W2092833488 @default.
• W2001139664 hasRelatedWork W2320944178 @default.
• W2001139664 hasRelatedWork W2376074723 @default.
• W2001139664 hasRelatedWork W3039750778 @default.
• W2001139664 hasRelatedWork W3140793150 @default.
• W2001139664 hasVolume "62" @default.
• W2001139664 isParatext "false" @default.
• W2001139664 isRetracted "false" @default.
• W2001139664 magId "2001139664" @default.

• next