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- W2001145596 abstract "In the embryonic and adult nervous system, neurotrophic and growth factors precisely regulate the timing and extent of neuronal differentiation, proliferation, and survival. Many of these factors bind to cell surface receptors with intrinsic tyrosine kinase activity. The binding of factor to a receptor tyrosine kinase stimulates its kinase activity, inducing the phosphorylation of the receptor and intracellular proteins on tyrosine residues. This chapter concentrates upon the study of signal transduction by receptor tyrosine kinases, using the Trk/neurotrophin receptor as a model system. The best studied neurotrophic factor is NGF, a member of the neurotrophin family that also includes BDNF, NT-3, NT-4/5, and NT-6. Mice in which either the neurotrophins or their receptors have been selectively deleted by homologous recombination display severe defects in peripheral and motor neurons. For example, the NGF knockout mice lose the neurons of the sympathetic ganglia soon after birth and show extensive loss of the thermosensitive and pain-sensitive sensory neurons of the dorsal root ganglia. Besides their influence on neuronal development, NGF and the other neurotrophins play important roles in the maintenance and repair of the adult nervous system, and have been implicated as both oncogenic agents and tumor suppressors in various human tumors." @default.
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- W2001145596 date "1996-06-01" @default.
- W2001145596 modified "2023-09-25" @default.
- W2001145596 title "Modulation of activity-dependent neuronal plasticity: A new facet of neurotrophin action" @default.
- W2001145596 doi "https://doi.org/10.1016/0924-977x(96)87743-1" @default.
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