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• W2001155840 startingPage "194" @default.
• W2001155840 abstract "Abstract Many have claimed that the sequencing of the human genome has failed to deliver the promised new era of drug discovery and development. Here, we argue that in fact, the availability of the human genome sequence and the genomics technologies that resulted from those research efforts have had a major impact on drug discovery. Medicinal chemists are actively using the data gleaned from structural genomics projects over the past decade to design more selective and more effective drug candidates. For example, large superfamilies of related enzymes, such as the kinome, proteome, proteasome, transportome, identified because of the sequencing of the human genome represent a huge number of potential drug targets. Ten years on, we′re able to design multitarget drugs where the selectivity for a certain subgroup of receptors can lead to increased efficacy rather than the side effects traditionally associated with “off‐targets”. New trends and discoveries in biomedical research are notoriously slow to show their value, and this is also true for genomics technologies. However, the examples we′ve selected show that these are firmly set in the drug‐discovery process, and without the human genome sequence, a number of current clinical candidates and promising drug leads would not have been possible." @default.
• W2001155840 created "2016-06-24" @default.
• W2001155840 creator A5012415692 @default.
• W2001155840 creator A5070067508 @default.
• W2001155840 date "2011-12-13" @default.
• W2001155840 modified "2023-10-16" @default.
• W2001155840 title "A Decade of the Human Genome Sequence-How Does the Medicinal Chemist Benefit?" @default.
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