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- W2001159550 abstract "A physical clone contig has been constructed, spanning 2 Mb on the proximal mouse X chromosome containing the mouse scurfy (sf) and tattered (Td) mutations. Extensive transcript mapping in this interval has identified 37 potential transcription units, including a number of novel genes, and 4 pseudogenes. These genes have been ordered by STS content and restriction mapping. Comparison of the transcript map to the corresponding region in human Xp11.23-p11.22 shows extensive homology, with complete conservation of gene order for loci in common between the two maps. Further, using a novel method to identify simple sequence length polymorphisms, we have developed a number of genetic markers, which has enabled the region containing the sf mutation to be narrowed to <300 kb. This contig has already allowed the cloning of the Td gene using a candidate gene approach and now serves as a starting point for the cloning of the sf mutation." @default.
- W2001159550 created "2016-06-24" @default.
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- W2001159550 date "2000-05-01" @default.
- W2001159550 modified "2023-10-07" @default.
- W2001159550 title "A Transcript Map of a 2-Mb BAC Contig in the Proximal Portion of the Mouse X Chromosome and Regional Mapping of the scurfy Mutation" @default.
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- W2001159550 doi "https://doi.org/10.1006/geno.2000.6173" @default.
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