Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001159891> ?p ?o ?g. }
- W2001159891 endingPage "425" @default.
- W2001159891 startingPage "415" @default.
- W2001159891 abstract "Engineered Fc-lacking bispecific antibodies have shown an exceptionally high potency for recruiting lymphocyte effector cells and enhancing antitumor activity, which is under evaluation in several clinical trials. However, current treatment regimens raise some issues that should be considered, such as the high cost of clinical-grade bispecific antibodies and the achievement of sustained therapeutic plasma levels. The use of gene transfer methods may circumvent problems related to large-scale production and purification, and result in sustained therapeutic plasma concentrations of the Fc-lacking bispecific antibodies. In fact, terminally differentiated cells and non-terminally differentiated cells can be genetically modified to secrete functionally active bispecific antibodies exerting clear anti-tumor effects. This review highlights the relevance of different promising strategies for in vivo delivery of therapeutic bispecific antibodies." @default.
- W2001159891 created "2016-06-24" @default.
- W2001159891 creator A5003276179 @default.
- W2001159891 creator A5009059698 @default.
- W2001159891 creator A5042598309 @default.
- W2001159891 creator A5089896171 @default.
- W2001159891 date "2013-06-27" @default.
- W2001159891 modified "2023-09-26" @default.
- W2001159891 title "In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells" @default.
- W2001159891 cites W1512026049 @default.
- W2001159891 cites W1848910860 @default.
- W2001159891 cites W1885690154 @default.
- W2001159891 cites W1966422780 @default.
- W2001159891 cites W1967971602 @default.
- W2001159891 cites W1975292043 @default.
- W2001159891 cites W1978368856 @default.
- W2001159891 cites W1982622656 @default.
- W2001159891 cites W1982969267 @default.
- W2001159891 cites W1983412131 @default.
- W2001159891 cites W1991644988 @default.
- W2001159891 cites W1991723371 @default.
- W2001159891 cites W1993575340 @default.
- W2001159891 cites W1993953211 @default.
- W2001159891 cites W1995233999 @default.
- W2001159891 cites W1997984454 @default.
- W2001159891 cites W1998836855 @default.
- W2001159891 cites W2000194482 @default.
- W2001159891 cites W2003130551 @default.
- W2001159891 cites W2003357246 @default.
- W2001159891 cites W2015853802 @default.
- W2001159891 cites W2021856189 @default.
- W2001159891 cites W2028239901 @default.
- W2001159891 cites W2033439473 @default.
- W2001159891 cites W2039060347 @default.
- W2001159891 cites W2043904711 @default.
- W2001159891 cites W2044795911 @default.
- W2001159891 cites W2051071528 @default.
- W2001159891 cites W2051297632 @default.
- W2001159891 cites W2060209794 @default.
- W2001159891 cites W2063845929 @default.
- W2001159891 cites W2065875656 @default.
- W2001159891 cites W2065997104 @default.
- W2001159891 cites W2068546732 @default.
- W2001159891 cites W2075395413 @default.
- W2001159891 cites W2075555864 @default.
- W2001159891 cites W2080694397 @default.
- W2001159891 cites W2084544749 @default.
- W2001159891 cites W2086146164 @default.
- W2001159891 cites W2087765617 @default.
- W2001159891 cites W2089004231 @default.
- W2001159891 cites W2098182642 @default.
- W2001159891 cites W2129477690 @default.
- W2001159891 cites W2141753215 @default.
- W2001159891 cites W2141815918 @default.
- W2001159891 cites W2143022774 @default.
- W2001159891 cites W2144805675 @default.
- W2001159891 cites W2148278891 @default.
- W2001159891 cites W2152442991 @default.
- W2001159891 cites W2169921558 @default.
- W2001159891 cites W2173414413 @default.
- W2001159891 cites W2225363868 @default.
- W2001159891 doi "https://doi.org/10.3390/antib2030415" @default.
- W2001159891 hasPublicationYear "2013" @default.
- W2001159891 type Work @default.
- W2001159891 sameAs 2001159891 @default.
- W2001159891 citedByCount "1" @default.
- W2001159891 countsByYear W20011598912017 @default.
- W2001159891 crossrefType "journal-article" @default.
- W2001159891 hasAuthorship W2001159891A5003276179 @default.
- W2001159891 hasAuthorship W2001159891A5009059698 @default.
- W2001159891 hasAuthorship W2001159891A5042598309 @default.
- W2001159891 hasAuthorship W2001159891A5089896171 @default.
- W2001159891 hasBestOaLocation W20011598911 @default.
- W2001159891 hasConcept C150903083 @default.
- W2001159891 hasConcept C159654299 @default.
- W2001159891 hasConcept C203014093 @default.
- W2001159891 hasConcept C207001950 @default.
- W2001159891 hasConcept C3020495827 @default.
- W2001159891 hasConcept C49039625 @default.
- W2001159891 hasConcept C502942594 @default.
- W2001159891 hasConcept C51785407 @default.
- W2001159891 hasConcept C542903549 @default.
- W2001159891 hasConcept C55493867 @default.
- W2001159891 hasConcept C86803240 @default.
- W2001159891 hasConceptScore W2001159891C150903083 @default.
- W2001159891 hasConceptScore W2001159891C159654299 @default.
- W2001159891 hasConceptScore W2001159891C203014093 @default.
- W2001159891 hasConceptScore W2001159891C207001950 @default.
- W2001159891 hasConceptScore W2001159891C3020495827 @default.
- W2001159891 hasConceptScore W2001159891C49039625 @default.
- W2001159891 hasConceptScore W2001159891C502942594 @default.
- W2001159891 hasConceptScore W2001159891C51785407 @default.
- W2001159891 hasConceptScore W2001159891C542903549 @default.
- W2001159891 hasConceptScore W2001159891C55493867 @default.
- W2001159891 hasConceptScore W2001159891C86803240 @default.
- W2001159891 hasIssue "4" @default.
- W2001159891 hasLocation W20011598911 @default.
- W2001159891 hasLocation W20011598912 @default.