Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001164369> ?p ?o ?g. }
- W2001164369 endingPage "603" @default.
- W2001164369 startingPage "597" @default.
- W2001164369 abstract "Cardiac fibrosis is a hallmark of cardiovascular remodeling associated with hypertension. The purpose of this study was to explore the effect and mechanism of soluble guanylate cyclase (sGC) stimulator BAY 41–2272, leading to intracellular cyclic guanosine monophosphate (cGMP) elevation, on the remodeling process induced by pressure overload. Seven-week-old male Wistar rats with hypertension induced by suprarenal aortic constriction (AC) were treated orally with 2 mg kg−1 day−1 of BAY 41–2272 for 14 days. BAY 41–2272 had no effects on blood pressure, but decreased AC-induced collagen accumulation in the left ventricle (LV), inhibiting the number of myofibroblasts and gene expressions of transforming growth factor-β1 and type 1 collagen. In addition, the antifibrotic action of BAY 41–2272 was accompanied by reducing AC-induced angiotensin-converting enzyme (ACE) mRNA and its enzymatic activity, and angiotensin II concentration in LV. In cultured cardiac fibroblasts, BAY 41–2272 inhibited ACE synthesis and myofibroblast transformation, accompanied by elevating the intracellular cGMP concentration. These results suggest that sGC stimulator BAY 41–2272 might be effective to reduce fibrosis in hypertensive heart disease by attenuating angiotensin II generation through myofibroblast transformation." @default.
- W2001164369 created "2016-06-24" @default.
- W2001164369 creator A5021146215 @default.
- W2001164369 creator A5023585627 @default.
- W2001164369 creator A5042187230 @default.
- W2001164369 creator A5044933503 @default.
- W2001164369 creator A5048075263 @default.
- W2001164369 creator A5051382077 @default.
- W2001164369 creator A5062421577 @default.
- W2001164369 creator A5080459636 @default.
- W2001164369 creator A5090599179 @default.
- W2001164369 date "2009-05-08" @default.
- W2001164369 modified "2023-10-11" @default.
- W2001164369 title "Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart" @default.
- W2001164369 cites W121290665 @default.
- W2001164369 cites W1583086572 @default.
- W2001164369 cites W1857709346 @default.
- W2001164369 cites W1964436833 @default.
- W2001164369 cites W1970926917 @default.
- W2001164369 cites W1986049576 @default.
- W2001164369 cites W2001926720 @default.
- W2001164369 cites W2023515446 @default.
- W2001164369 cites W2024711033 @default.
- W2001164369 cites W2026166943 @default.
- W2001164369 cites W2027764827 @default.
- W2001164369 cites W2030245809 @default.
- W2001164369 cites W2035137607 @default.
- W2001164369 cites W2037034743 @default.
- W2001164369 cites W2037749195 @default.
- W2001164369 cites W2043863070 @default.
- W2001164369 cites W2054935021 @default.
- W2001164369 cites W2061213014 @default.
- W2001164369 cites W2081223179 @default.
- W2001164369 cites W2104357833 @default.
- W2001164369 cites W2105050893 @default.
- W2001164369 cites W2114646530 @default.
- W2001164369 cites W2120553703 @default.
- W2001164369 cites W2122254336 @default.
- W2001164369 cites W2122973528 @default.
- W2001164369 cites W2125086507 @default.
- W2001164369 cites W2125965373 @default.
- W2001164369 cites W2132106701 @default.
- W2001164369 cites W2136718447 @default.
- W2001164369 cites W2147900744 @default.
- W2001164369 cites W2155014420 @default.
- W2001164369 cites W2159804480 @default.
- W2001164369 cites W2167556957 @default.
- W2001164369 cites W2188064034 @default.
- W2001164369 cites W2207297727 @default.
- W2001164369 cites W2331253441 @default.
- W2001164369 cites W2340874696 @default.
- W2001164369 doi "https://doi.org/10.1038/hr.2009.64" @default.
- W2001164369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19424280" @default.
- W2001164369 hasPublicationYear "2009" @default.
- W2001164369 type Work @default.
- W2001164369 sameAs 2001164369 @default.
- W2001164369 citedByCount "67" @default.
- W2001164369 countsByYear W20011643692012 @default.
- W2001164369 countsByYear W20011643692013 @default.
- W2001164369 countsByYear W20011643692014 @default.
- W2001164369 countsByYear W20011643692015 @default.
- W2001164369 countsByYear W20011643692016 @default.
- W2001164369 countsByYear W20011643692017 @default.
- W2001164369 countsByYear W20011643692018 @default.
- W2001164369 countsByYear W20011643692019 @default.
- W2001164369 countsByYear W20011643692020 @default.
- W2001164369 countsByYear W20011643692021 @default.
- W2001164369 countsByYear W20011643692022 @default.
- W2001164369 countsByYear W20011643692023 @default.
- W2001164369 crossrefType "journal-article" @default.
- W2001164369 hasAuthorship W2001164369A5021146215 @default.
- W2001164369 hasAuthorship W2001164369A5023585627 @default.
- W2001164369 hasAuthorship W2001164369A5042187230 @default.
- W2001164369 hasAuthorship W2001164369A5044933503 @default.
- W2001164369 hasAuthorship W2001164369A5048075263 @default.
- W2001164369 hasAuthorship W2001164369A5051382077 @default.
- W2001164369 hasAuthorship W2001164369A5062421577 @default.
- W2001164369 hasAuthorship W2001164369A5080459636 @default.
- W2001164369 hasAuthorship W2001164369A5090599179 @default.
- W2001164369 hasBestOaLocation W20011643691 @default.
- W2001164369 hasConcept C126322002 @default.
- W2001164369 hasConcept C134018914 @default.
- W2001164369 hasConcept C173803235 @default.
- W2001164369 hasConcept C185592680 @default.
- W2001164369 hasConcept C198710026 @default.
- W2001164369 hasConcept C207865475 @default.
- W2001164369 hasConcept C2777420927 @default.
- W2001164369 hasConcept C2778198053 @default.
- W2001164369 hasConcept C2778271984 @default.
- W2001164369 hasConcept C2778827303 @default.
- W2001164369 hasConcept C2778921608 @default.
- W2001164369 hasConcept C2780559512 @default.
- W2001164369 hasConcept C2780994212 @default.
- W2001164369 hasConcept C2908929049 @default.
- W2001164369 hasConcept C3018791406 @default.
- W2001164369 hasConcept C519581460 @default.
- W2001164369 hasConcept C55493867 @default.
- W2001164369 hasConcept C71924100 @default.