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- W2001165441 abstract "β-N-METHYLAMINO-L-ALAMNE (L-BMAA) is an excitotoxin whose neurodegenerative effects are associated with its agonist properties at the N-methyl-D-aspartate (NMDA) receptor. We measured the effects of L-BMAA on inositol phosphate (InsP) formation in primary cultured striatal neurons. This culture is almost devoid of glial cells and the pharmacology of glutamate receptors is well-defined. This allowed us to show that L-BMAA induced InsP formation via a direct action at the glutamate metabotropic (Qp) receptors coupled to InsP formation. We demonstrated that L-BMAA is a full-agonist of the Qp receptor, but with a low potency. Therefore, the neurotoxic properties of L-BMAA might implicate the activation of the Qp receptor in association with the NMDA receptor." @default.
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- W2001165441 date "1991-10-01" @default.
- W2001165441 modified "2023-10-03" @default.
- W2001165441 title "β-N-methylamino-L-alanine is a low-affinity agonist of metabotropic glutamate receptors" @default.
- W2001165441 doi "https://doi.org/10.1097/00001756-199110000-00014" @default.
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