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• W2001165907 abstract "Gonadotropin-inhibitory hormone (GnIH) is a neuropeptide inhibitor of gonadotropin secretion, which was first identified in the Japanese quail hypothalamus. GnIH peptides share a C-terminal LPXRFamide (X=L or Q) motif in most vertebrates. The receptor for GnIH (GnIHR) is the seven-transmembrane G protein-coupled receptor 147 (GPR147) that inhibits cAMP production. GPR147 is also named neuropeptide FF (NPFF) receptor 1 (NPFFR1), because it also binds NPFF that has a C-terminal PQRFamide motif. To understand the evolutionary history of the GnIH system in the animal kingdom, we searched for receptors structurally similar to GnIHR in the genome of six mammals (human, mouse, rat, cattle, cat, and rabbit), five birds (pigeon, chicken, turkey, budgerigar, and zebra finch), one reptile (green anole), one amphibian (Western clawed flog), six fishes (zebrafish, Nile tilapia, Fugu, coelacanth, spotted gar, and lamprey), one hemichordate (acorn worm), one echinoderm (purple sea urchin), one mollusk (California sea hare), seven insects (pea aphid, African malaria mosquito, honey bee, buff-tailed bumblebee, fruit fly, jewel wasp, and red flour beetle), one cnidarian (hydra), and constructed phylogenetic trees by neighbor joining (NJ) and maximum likelihood (ML) methods. A multiple sequence alignment of the receptors showed highly conserved seven-transmembrane domains as well as disulfide bridge sites between the first and second extracellular loops, including the receptor of hydra. Both NJ and ML analyses grouped the receptors of vertebrates into NPFFR1 and NPFFR2 (GPR74), and the receptors of insects into the receptor for SIFamide peptides that share a C-terminal YRKPPFNGSIFamide motif. Although human, quail and zebrafish GnIHR (NPFFR1) were most structurally similar to SIFamide receptor of fruit fly in the Famide peptide (FMRFamide, neuropeptide F, short neuropeptide F, drosulfakinin, myosuppressin, SIFamide) receptor families, the amino acid sequences and the peptide coding regions of GnIH precursors were most similar to FMRFamide precursor of fruit fly in the precursors of Famide peptide families. Chromosome synteny analysis of the precursor genes of human, quail and zebrafish GnIH and fruit fly Famide peptides further identified conserved synteny in vertebrate GnIH and fruit fly FMRFa precursor genes as well as other Famide peptide precursor genes. These results suggest that GnIH and its receptor pair and SIFamide and its receptor pair may have diverged and co-evolved independently in vertebrates and insects, respectively, from their ancestral Famide peptide and its receptor pair, during diversification and evolution of deuterostomian and protostomian species." @default.
• W2001165907 created "2016-06-24" @default.
• W2001165907 creator A5056428219 @default.
• W2001165907 creator A5074471026 @default.
• W2001165907 date "2014-12-01" @default.
• W2001165907 modified "2023-10-11" @default.
• W2001165907 title "Evolution of gonadotropin-inhibitory hormone receptor and its ligand" @default.
• W2001165907 cites W1506809457 @default.
• W2001165907 cites W1540547666 @default.
• W2001165907 cites W1545663099 @default.
• W2001165907 cites W1575830009 @default.
• W2001165907 cites W1879451279 @default.
• W2001165907 cites W1894424824 @default.
• W2001165907 cites W1963630241 @default.
• W2001165907 cites W1968084526 @default.
• W2001165907 cites W1970334814 @default.
• W2001165907 cites W1975019750 @default.
• W2001165907 cites W1976066594 @default.
• W2001165907 cites W1986765859 @default.
• W2001165907 cites W1987691900 @default.
• W2001165907 cites W1988576006 @default.
• W2001165907 cites W1988896334 @default.
• W2001165907 cites W1989260936 @default.
• W2001165907 cites W1995046253 @default.
• W2001165907 cites W1997090548 @default.
• W2001165907 cites W1999266526 @default.
• W2001165907 cites W1999918497 @default.
• W2001165907 cites W2001249706 @default.
• W2001165907 cites W2001936817 @default.
• W2001165907 cites W2005228725 @default.
• W2001165907 cites W2007698195 @default.
• W2001165907 cites W2009424714 @default.
• W2001165907 cites W2010491214 @default.
• W2001165907 cites W2015865718 @default.
• W2001165907 cites W2022044685 @default.
• W2001165907 cites W2028546888 @default.
• W2001165907 cites W2029050696 @default.
• W2001165907 cites W2030170444 @default.
• W2001165907 cites W2030957103 @default.
• W2001165907 cites W2033011212 @default.
• W2001165907 cites W2037239458 @default.
• W2001165907 cites W2037462455 @default.
• W2001165907 cites W2038718458 @default.
• W2001165907 cites W2043129540 @default.
• W2001165907 cites W2044447469 @default.
• W2001165907 cites W2046494491 @default.
• W2001165907 cites W2046637025 @default.
• W2001165907 cites W2047405437 @default.
• W2001165907 cites W2051400867 @default.
• W2001165907 cites W2051702632 @default.
• W2001165907 cites W2052069887 @default.
• W2001165907 cites W2055517724 @default.
• W2001165907 cites W2055660125 @default.
• W2001165907 cites W2059555361 @default.
• W2001165907 cites W2063896926 @default.
• W2001165907 cites W2064802392 @default.
• W2001165907 cites W2067018731 @default.
• W2001165907 cites W2076355203 @default.
• W2001165907 cites W2076766773 @default.
• W2001165907 cites W2077412978 @default.
• W2001165907 cites W2083323779 @default.
• W2001165907 cites W2092595147 @default.
• W2001165907 cites W2096532127 @default.
• W2001165907 cites W2098240153 @default.
• W2001165907 cites W2100733933 @default.
• W2001165907 cites W2102771515 @default.
• W2001165907 cites W2104172367 @default.
• W2001165907 cites W2109014958 @default.
• W2001165907 cites W2113887382 @default.
• W2001165907 cites W2116806096 @default.
• W2001165907 cites W2116996675 @default.
• W2001165907 cites W2117919289 @default.
• W2001165907 cites W2118475136 @default.
• W2001165907 cites W2120636942 @default.
• W2001165907 cites W2126705075 @default.
• W2001165907 cites W2128682042 @default.
• W2001165907 cites W2140360329 @default.
• W2001165907 cites W2142793823 @default.
• W2001165907 cites W2146989051 @default.
• W2001165907 cites W2150149607 @default.
• W2001165907 cites W2151733775 @default.
• W2001165907 cites W2152207030 @default.
• W2001165907 cites W2154229040 @default.
• W2001165907 cites W2154775029 @default.
• W2001165907 cites W2166905473 @default.
• W2001165907 cites W2167758432 @default.
• W2001165907 cites W2169601302 @default.
• W2001165907 cites W4243812446 @default.
• W2001165907 cites W4251828057 @default.
• W2001165907 doi "https://doi.org/10.1016/j.ygcen.2014.09.002" @default.
• W2001165907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25220854" @default.
• W2001165907 hasPublicationYear "2014" @default.
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