FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001181414> ?p ?o ?g. }

• W2001181414 endingPage "386" @default.
• W2001181414 startingPage "380" @default.
• W2001181414 abstract "It is crucial to enhance tumor radiosensitivity for the purpose of both lowering the dose of ionizing radiation (IR) and achieving higher antitumor efficacy. We identified curcumin as a radiosensitizer to enhance non-Hodgkin's lymphoma (NHL) cell response to IR in vitro and further investigated the mechanism mediating this effect. We treated Namalwa, Ramos and Raji cell lines with vehicle, curcumin, IR and curcumin-IR. Cell viability and cell cycle distribution were determined to ascertain the radiosensitization effect of curcumin. DNA damage-related proteins, cell cycle regulatory proteins, phosphorylation of mammalian target of rapamycin (mTOR) and the nuclear translocation of the downstream nuclear factor-κB (NF-κB) target were examined by western blotting. Treatment with curcumin led to decreased viability of all three types of NHL cells and had a profound radiosensitization effect. Pre-treatment with curcumin at a low concentration of 2 µmol/l increased IR-induced G2/M arrest in the cell cycle and increased the expression of cyclin-dependent kinase inhibitors, p21cip1 and p53. However, this effect was blocked when NHL cells were pre-treated with 10 µmol/l of KU55933, a specific inhibitor of ataxia-telangiectasia-mutated (ATM). Pre-treatment with curcumin inhibited the phosphorylation of mTOR and the nuclear translocation of the downstream NF-κB target induced by IR. Curcumin enhanced the cell response to IR in NHL mediated through the induction of G2/M phase arrest and the inhibition of both a constitutive and IR-induced activation of the mTOR-NF-κB pathway. This offers great potential for curcumin to be used in conjunction with radiotherapy for NHL in order to increase the efficiency of the treatment." @default.
• W2001181414 created "2016-06-24" @default.
• W2001181414 creator A5018721355 @default.
• W2001181414 creator A5055328507 @default.
• W2001181414 creator A5071060953 @default.
• W2001181414 date "2012-10-19" @default.
• W2001181414 modified "2023-10-13" @default.
• W2001181414 title "Curcumin enhances the response of non-Hodgkin’s lymphoma cells to ionizing radiation through further induction of cell cycle arrest at the G2/M phase and inhibition of mTOR phosphorylation" @default.
• W2001181414 cites W1967880683 @default.
• W2001181414 cites W1973823907 @default.
• W2001181414 cites W1981232450 @default.
• W2001181414 cites W1982328696 @default.
• W2001181414 cites W1982397837 @default.
• W2001181414 cites W1987811570 @default.
• W2001181414 cites W1998533565 @default.
• W2001181414 cites W2001106708 @default.
• W2001181414 cites W2013115296 @default.
• W2001181414 cites W2015749195 @default.
• W2001181414 cites W2018668167 @default.
• W2001181414 cites W2032010345 @default.
• W2001181414 cites W2038146198 @default.
• W2001181414 cites W2038259382 @default.
• W2001181414 cites W2045324074 @default.
• W2001181414 cites W2053663898 @default.
• W2001181414 cites W2081022172 @default.
• W2001181414 cites W2091884040 @default.
• W2001181414 cites W2101464901 @default.
• W2001181414 cites W2101988823 @default.
• W2001181414 cites W2104093590 @default.
• W2001181414 cites W2110604215 @default.
• W2001181414 cites W2116375511 @default.
• W2001181414 cites W2120942865 @default.
• W2001181414 cites W2126635650 @default.
• W2001181414 cites W2126895514 @default.
• W2001181414 cites W2127621044 @default.
• W2001181414 cites W2141018935 @default.
• W2001181414 cites W2141983633 @default.
• W2001181414 cites W2144323747 @default.
• W2001181414 cites W2155567086 @default.
• W2001181414 cites W2165450197 @default.
• W2001181414 cites W2170460353 @default.
• W2001181414 cites W2171352831 @default.
• W2001181414 cites W2172024684 @default.
• W2001181414 cites W4249795909 @default.
• W2001181414 cites W2079969012 @default.
• W2001181414 doi "https://doi.org/10.3892/or.2012.2091" @default.
• W2001181414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23117293" @default.
• W2001181414 hasPublicationYear "2012" @default.
• W2001181414 type Work @default.
• W2001181414 sameAs 2001181414 @default.
• W2001181414 citedByCount "27" @default.
• W2001181414 countsByYear W20011814142014 @default.
• W2001181414 countsByYear W20011814142015 @default.
• W2001181414 countsByYear W20011814142016 @default.
• W2001181414 countsByYear W20011814142017 @default.
• W2001181414 countsByYear W20011814142018 @default.
• W2001181414 countsByYear W20011814142019 @default.
• W2001181414 countsByYear W20011814142020 @default.
• W2001181414 countsByYear W20011814142021 @default.
• W2001181414 countsByYear W20011814142022 @default.
• W2001181414 countsByYear W20011814142023 @default.
• W2001181414 crossrefType "journal-article" @default.
• W2001181414 hasAuthorship W2001181414A5018721355 @default.
• W2001181414 hasAuthorship W2001181414A5055328507 @default.
• W2001181414 hasAuthorship W2001181414A5071060953 @default.
• W2001181414 hasBestOaLocation W20011814141 @default.
• W2001181414 hasConcept C105696609 @default.
• W2001181414 hasConcept C11960822 @default.
• W2001181414 hasConcept C126322002 @default.
• W2001181414 hasConcept C1491633281 @default.
• W2001181414 hasConcept C185592680 @default.
• W2001181414 hasConcept C206684579 @default.
• W2001181414 hasConcept C2778250585 @default.
• W2001181414 hasConcept C29537977 @default.
• W2001181414 hasConcept C502942594 @default.
• W2001181414 hasConcept C509974204 @default.
• W2001181414 hasConcept C53227056 @default.
• W2001181414 hasConcept C55493867 @default.
• W2001181414 hasConcept C62478195 @default.
• W2001181414 hasConcept C71924100 @default.
• W2001181414 hasConcept C75217442 @default.
• W2001181414 hasConcept C86554907 @default.
• W2001181414 hasConcept C86803240 @default.
• W2001181414 hasConcept C95444343 @default.
• W2001181414 hasConcept C98274493 @default.
• W2001181414 hasConceptScore W2001181414C105696609 @default.
• W2001181414 hasConceptScore W2001181414C11960822 @default.
• W2001181414 hasConceptScore W2001181414C126322002 @default.
• W2001181414 hasConceptScore W2001181414C1491633281 @default.
• W2001181414 hasConceptScore W2001181414C185592680 @default.
• W2001181414 hasConceptScore W2001181414C206684579 @default.
• W2001181414 hasConceptScore W2001181414C2778250585 @default.
• W2001181414 hasConceptScore W2001181414C29537977 @default.
• W2001181414 hasConceptScore W2001181414C502942594 @default.
• W2001181414 hasConceptScore W2001181414C509974204 @default.
• W2001181414 hasConceptScore W2001181414C53227056 @default.
• W2001181414 hasConceptScore W2001181414C55493867 @default.
• W2001181414 hasConceptScore W2001181414C62478195 @default.

• next