FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001185259> ?p ?o ?g. }

• W2001185259 endingPage "14533" @default.
• W2001185259 startingPage "14528" @default.
• W2001185259 abstract "Stable multipartite mutualistic associations require that all partners benefit. We show that a single mutational step is sufficient to turn a symbiotic bacterium from an inedible but host-beneficial secondary metabolite producer into a host food source. The bacteria’s host is a “farmer” clone of the social amoeba Dictyostelium discoideum that carries and disperses bacteria during its spore stage. Associated with the farmer are two strains of Pseudomonas fluorescens , only one of which serves as a food source. The other strain produces diffusible small molecules: pyrrolnitrin, a known antifungal agent, and a chromene that potently enhances the farmer’s spore production and depresses a nonfarmer’s spore production. Genome sequence and phylogenetic analyses identify a derived point mutation in the food strain that generates a premature stop codon in a global activator ( gacA ), encoding the response regulator of a two-component regulatory system. Generation of a knockout mutant of this regulatory gene in the nonfood bacterial strain altered its secondary metabolite profile to match that of the food strain, and also, independently, converted it into a food source. These results suggest that a single mutation in an inedible ancestral strain that served a protective role converted it to a “domesticated” food source." @default.
• W2001185259 created "2016-06-24" @default.
• W2001185259 creator A5008067693 @default.
• W2001185259 creator A5012967730 @default.
• W2001185259 creator A5015968014 @default.
• W2001185259 creator A5025206050 @default.
• W2001185259 creator A5039698117 @default.
• W2001185259 creator A5042251634 @default.
• W2001185259 creator A5065678849 @default.
• W2001185259 date "2013-07-29" @default.
• W2001185259 modified "2023-10-11" @default.
• W2001185259 title "A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the <i>gacA</i> gene" @default.
• W2001185259 cites W1569023363 @default.
• W2001185259 cites W1580699884 @default.
• W2001185259 cites W1666537385 @default.
• W2001185259 cites W1939764576 @default.
• W2001185259 cites W1988555371 @default.
• W2001185259 cites W1990421064 @default.
• W2001185259 cites W1991774743 @default.
• W2001185259 cites W1997810660 @default.
• W2001185259 cites W2001548763 @default.
• W2001185259 cites W2006702818 @default.
• W2001185259 cites W2009930767 @default.
• W2001185259 cites W2009948900 @default.
• W2001185259 cites W2020057555 @default.
• W2001185259 cites W2029783392 @default.
• W2001185259 cites W2032793307 @default.
• W2001185259 cites W2033337708 @default.
• W2001185259 cites W2036325355 @default.
• W2001185259 cites W2039467082 @default.
• W2001185259 cites W2047168915 @default.
• W2001185259 cites W2049959020 @default.
• W2001185259 cites W2051397923 @default.
• W2001185259 cites W2065188354 @default.
• W2001185259 cites W2067356508 @default.
• W2001185259 cites W2074044150 @default.
• W2001185259 cites W2074308942 @default.
• W2001185259 cites W2075158754 @default.
• W2001185259 cites W2076546617 @default.
• W2001185259 cites W2092268570 @default.
• W2001185259 cites W2094143402 @default.
• W2001185259 cites W2103441770 @default.
• W2001185259 cites W2104503310 @default.
• W2001185259 cites W2108048523 @default.
• W2001185259 cites W2108234281 @default.
• W2001185259 cites W2109304737 @default.
• W2001185259 cites W2116107007 @default.
• W2001185259 cites W2122197684 @default.
• W2001185259 cites W2132632499 @default.
• W2001185259 cites W2147051160 @default.
• W2001185259 cites W2148615699 @default.
• W2001185259 cites W2149441828 @default.
• W2001185259 cites W2160896221 @default.
• W2001185259 cites W4233668924 @default.
• W2001185259 cites W4376848606 @default.
• W2001185259 doi "https://doi.org/10.1073/pnas.1308199110" @default.
• W2001185259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3767522" @default.
• W2001185259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23898207" @default.
• W2001185259 hasPublicationYear "2013" @default.
• W2001185259 type Work @default.
• W2001185259 sameAs 2001185259 @default.
• W2001185259 citedByCount "58" @default.
• W2001185259 countsByYear W20011852592013 @default.
• W2001185259 countsByYear W20011852592014 @default.
• W2001185259 countsByYear W20011852592015 @default.
• W2001185259 countsByYear W20011852592016 @default.
• W2001185259 countsByYear W20011852592017 @default.
• W2001185259 countsByYear W20011852592018 @default.
• W2001185259 countsByYear W20011852592019 @default.
• W2001185259 countsByYear W20011852592020 @default.
• W2001185259 countsByYear W20011852592021 @default.
• W2001185259 countsByYear W20011852592022 @default.
• W2001185259 countsByYear W20011852592023 @default.
• W2001185259 crossrefType "journal-article" @default.
• W2001185259 hasAuthorship W2001185259A5008067693 @default.
• W2001185259 hasAuthorship W2001185259A5012967730 @default.
• W2001185259 hasAuthorship W2001185259A5015968014 @default.
• W2001185259 hasAuthorship W2001185259A5025206050 @default.
• W2001185259 hasAuthorship W2001185259A5039698117 @default.
• W2001185259 hasAuthorship W2001185259A5042251634 @default.
• W2001185259 hasAuthorship W2001185259A5065678849 @default.
• W2001185259 hasBestOaLocation W20011852591 @default.
• W2001185259 hasConcept C104317684 @default.
• W2001185259 hasConcept C105702510 @default.
• W2001185259 hasConcept C143065580 @default.
• W2001185259 hasConcept C2775969001 @default.
• W2001185259 hasConcept C2776835041 @default.
• W2001185259 hasConcept C2777347573 @default.
• W2001185259 hasConcept C2778022156 @default.
• W2001185259 hasConcept C523546767 @default.
• W2001185259 hasConcept C54355233 @default.
• W2001185259 hasConcept C86803240 @default.
• W2001185259 hasConcept C89423630 @default.
• W2001185259 hasConceptScore W2001185259C104317684 @default.
• W2001185259 hasConceptScore W2001185259C105702510 @default.
• W2001185259 hasConceptScore W2001185259C143065580 @default.
• W2001185259 hasConceptScore W2001185259C2775969001 @default.
• W2001185259 hasConceptScore W2001185259C2776835041 @default.

• next