Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001192334> ?p ?o ?g. }
- W2001192334 endingPage "1418" @default.
- W2001192334 startingPage "1405" @default.
- W2001192334 abstract "The Na+/Ca2+ exchanger (NCX) is a membrane transporter that can switch Na+ and Ca2+ in either direction to maintain the homeostasis of intracellular Ca2+. Three isoforms (NCX1, NCX2, and NCX3) have been characterized in excitable cells, e.g. neurons and muscle cells. We examined the expression of these NCX isoforms in primary human lung macrophages (HLM) and blood monocytes. NCX1 and NCX3, but not NCX2, are expressed in HLM and monocytes at both mRNA and protein levels. Na+-free medium induced a significant increase in intracellular calcium concentration ([Ca2+]i) in both cell types. This response was completely abolished by the NCX inhibitor 5-(N-4-chlorobenzyl)-20,40-dimethylbenzamil (CB-DMB). Moreover, inhibition of NCX activity during Ca2+-signaling induced by histamine caused a delay in restoring baseline [Ca2+]i. Na+-free medium induced TNF-α expression and release in HLM comparable to that caused by LPS. TNF-α release induced by Na+-free medium was blocked by CB-DMB and greatly reduced by RNAi-mediated knockdown of NCX1. These results indicate that human macrophages and monocytes express NCX1 and NCX3 that operate in a bidirectional manner to restore [Ca2+]i, to generate Ca2+-signals, and to induce TNF-α production. Therefore, NCX may contribute to regulate Ca2+ homeostasis and proinflammatory functions in human macrophages and monocytes." @default.
- W2001192334 created "2016-06-24" @default.
- W2001192334 creator A5004116646 @default.
- W2001192334 creator A5017635715 @default.
- W2001192334 creator A5038256842 @default.
- W2001192334 creator A5040903631 @default.
- W2001192334 creator A5071813092 @default.
- W2001192334 creator A5079235615 @default.
- W2001192334 creator A5087009055 @default.
- W2001192334 creator A5088001388 @default.
- W2001192334 creator A5089722463 @default.
- W2001192334 date "2009-04-06" @default.
- W2001192334 modified "2023-09-24" @default.
- W2001192334 title "Expression and function of Na+/Ca2+ exchangers 1 and 3 in human macrophages and monocytes" @default.
- W2001192334 cites W1856790100 @default.
- W2001192334 cites W1891661735 @default.
- W2001192334 cites W1927586615 @default.
- W2001192334 cites W1969234332 @default.
- W2001192334 cites W1973245046 @default.
- W2001192334 cites W1978270835 @default.
- W2001192334 cites W1980776191 @default.
- W2001192334 cites W1981165354 @default.
- W2001192334 cites W1983562761 @default.
- W2001192334 cites W1995371547 @default.
- W2001192334 cites W1997677285 @default.
- W2001192334 cites W2007887289 @default.
- W2001192334 cites W2012145933 @default.
- W2001192334 cites W2015141049 @default.
- W2001192334 cites W2017870178 @default.
- W2001192334 cites W2021460711 @default.
- W2001192334 cites W2026668394 @default.
- W2001192334 cites W2026696517 @default.
- W2001192334 cites W2049299592 @default.
- W2001192334 cites W2054581136 @default.
- W2001192334 cites W2055688488 @default.
- W2001192334 cites W2062266980 @default.
- W2001192334 cites W2063961981 @default.
- W2001192334 cites W2069358534 @default.
- W2001192334 cites W2070761382 @default.
- W2001192334 cites W2078713240 @default.
- W2001192334 cites W2079352525 @default.
- W2001192334 cites W2082468840 @default.
- W2001192334 cites W2087140031 @default.
- W2001192334 cites W2089063033 @default.
- W2001192334 cites W2090972591 @default.
- W2001192334 cites W2091798331 @default.
- W2001192334 cites W2093705034 @default.
- W2001192334 cites W2096436185 @default.
- W2001192334 cites W2100225253 @default.
- W2001192334 cites W2115420863 @default.
- W2001192334 cites W2115547927 @default.
- W2001192334 cites W2115884335 @default.
- W2001192334 cites W2123106811 @default.
- W2001192334 cites W2125145754 @default.
- W2001192334 cites W2125155338 @default.
- W2001192334 cites W2134786188 @default.
- W2001192334 cites W2135852424 @default.
- W2001192334 cites W2136221789 @default.
- W2001192334 cites W2141260882 @default.
- W2001192334 cites W2145514251 @default.
- W2001192334 cites W2147934559 @default.
- W2001192334 cites W2150488202 @default.
- W2001192334 cites W2153267812 @default.
- W2001192334 cites W2156174515 @default.
- W2001192334 cites W2159232436 @default.
- W2001192334 cites W2159367422 @default.
- W2001192334 cites W2160939409 @default.
- W2001192334 cites W2161251100 @default.
- W2001192334 cites W2170004689 @default.
- W2001192334 cites W2188376552 @default.
- W2001192334 cites W2316008801 @default.
- W2001192334 cites W2335815721 @default.
- W2001192334 cites W2340062477 @default.
- W2001192334 cites W4296587586 @default.
- W2001192334 doi "https://doi.org/10.1002/eji.200838792" @default.
- W2001192334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19350557" @default.
- W2001192334 hasPublicationYear "2009" @default.
- W2001192334 type Work @default.
- W2001192334 sameAs 2001192334 @default.
- W2001192334 citedByCount "40" @default.
- W2001192334 countsByYear W20011923342012 @default.
- W2001192334 countsByYear W20011923342013 @default.
- W2001192334 countsByYear W20011923342014 @default.
- W2001192334 countsByYear W20011923342015 @default.
- W2001192334 countsByYear W20011923342016 @default.
- W2001192334 countsByYear W20011923342017 @default.
- W2001192334 countsByYear W20011923342018 @default.
- W2001192334 countsByYear W20011923342019 @default.
- W2001192334 countsByYear W20011923342020 @default.
- W2001192334 countsByYear W20011923342021 @default.
- W2001192334 crossrefType "journal-article" @default.
- W2001192334 hasAuthorship W2001192334A5004116646 @default.
- W2001192334 hasAuthorship W2001192334A5017635715 @default.
- W2001192334 hasAuthorship W2001192334A5038256842 @default.
- W2001192334 hasAuthorship W2001192334A5040903631 @default.
- W2001192334 hasAuthorship W2001192334A5071813092 @default.
- W2001192334 hasAuthorship W2001192334A5079235615 @default.
- W2001192334 hasAuthorship W2001192334A5087009055 @default.