FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001193188> ?p ?o ?g. }

• W2001193188 endingPage "1655" @default.
• W2001193188 startingPage "1647" @default.
• W2001193188 abstract "The RecQ helicase superfamily has been implicated in DNA repair and recombination. At least five human RecQ-related genes exist: RecQ1, BLM, WRN, RecQ4 and RecQ5. Mutations in BLM, WRN and RecQ4 are associated with Bloom, Werner and Rothmund-Thomson syndromes, respectively, involving a predisposition to malignancies and a cellular phenotype that includes increased chromosome instability. RecQ5 is small, containing only a core part of the RecQ helicase, but three isomer transcripts code for small RecQ5α (corresponding to the original RecQ5 with 410 amino acids), new large RecQ5β (991 amino acids) and small RecQ5γ (435 amino acids) proteins that contain the core helicase motifs. By determining the genomic structure, we found that the three isoforms are generated by differential splicing from the RecQ5 gene that contains at least 19 exons. Northern blot analysis using a RecQ5β-specific probe indicates that RecQ5β mRNA is expressed strongly in the testis. Immunocytochemical staining of three N-terminally tagged RecQ5 isomers expressed in 293EBNA cells showed that RecQ5β migrates to the nucleus and exists exclusively in the nucleoplasm, while the small RecQ5α and RecQ5γ proteins stay in the cytoplasm. Immunoprecipitation and an extended cytochemical experiment suggested that the nucleoplasmic RecQ5β, like yeast Sgs1 DNA helicase, binds to topoisomerases 3α and 3β, but not to topoisomerase 1. These results predict that RecQ5β may have an important role in DNA metabolism and may also be related to a distinct genetic disease." @default.
• W2001193188 created "2016-06-24" @default.
• W2001193188 creator A5000544104 @default.
• W2001193188 creator A5048873795 @default.
• W2001193188 creator A5070449635 @default.
• W2001193188 creator A5071830752 @default.
• W2001193188 date "2000-04-01" @default.
• W2001193188 modified "2023-09-25" @default.
• W2001193188 title "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta" @default.
• W2001193188 cites W1538603370 @default.
• W2001193188 cites W1542472052 @default.
• W2001193188 cites W172772731 @default.
• W2001193188 cites W1907299583 @default.
• W2001193188 cites W1935801587 @default.
• W2001193188 cites W1966347623 @default.
• W2001193188 cites W1969336380 @default.
• W2001193188 cites W1970898019 @default.
• W2001193188 cites W1977518145 @default.
• W2001193188 cites W1989971670 @default.
• W2001193188 cites W1990262836 @default.
• W2001193188 cites W1996474984 @default.
• W2001193188 cites W2013432850 @default.
• W2001193188 cites W2017814216 @default.
• W2001193188 cites W2019044101 @default.
• W2001193188 cites W2032162552 @default.
• W2001193188 cites W2038603849 @default.
• W2001193188 cites W2050717008 @default.
• W2001193188 cites W2058094663 @default.
• W2001193188 cites W2059848377 @default.
• W2001193188 cites W2064310741 @default.
• W2001193188 cites W2066026298 @default.
• W2001193188 cites W2070781513 @default.
• W2001193188 cites W2071924188 @default.
• W2001193188 cites W2073483575 @default.
• W2001193188 cites W2077805593 @default.
• W2001193188 cites W2078030859 @default.
• W2001193188 cites W2085081661 @default.
• W2001193188 cites W2086725260 @default.
• W2001193188 cites W2086826197 @default.
• W2001193188 cites W2092527060 @default.
• W2001193188 cites W2097798503 @default.
• W2001193188 cites W2109714973 @default.
• W2001193188 cites W2111202021 @default.
• W2001193188 cites W2119245063 @default.
• W2001193188 cites W2124062248 @default.
• W2001193188 cites W2125905180 @default.
• W2001193188 cites W2127550258 @default.
• W2001193188 cites W2145304961 @default.
• W2001193188 cites W2153043528 @default.
• W2001193188 doi "https://doi.org/10.1093/nar/28.7.1647" @default.
• W2001193188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/102787" @default.
• W2001193188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10710432" @default.
• W2001193188 hasPublicationYear "2000" @default.
• W2001193188 type Work @default.
• W2001193188 sameAs 2001193188 @default.
• W2001193188 citedByCount "138" @default.
• W2001193188 countsByYear W20011931882012 @default.
• W2001193188 countsByYear W20011931882013 @default.
• W2001193188 countsByYear W20011931882014 @default.
• W2001193188 countsByYear W20011931882015 @default.
• W2001193188 countsByYear W20011931882016 @default.
• W2001193188 countsByYear W20011931882017 @default.
• W2001193188 countsByYear W20011931882019 @default.
• W2001193188 countsByYear W20011931882020 @default.
• W2001193188 countsByYear W20011931882021 @default.
• W2001193188 countsByYear W20011931882022 @default.
• W2001193188 countsByYear W20011931882023 @default.
• W2001193188 crossrefType "journal-article" @default.
• W2001193188 hasAuthorship W2001193188A5000544104 @default.
• W2001193188 hasAuthorship W2001193188A5048873795 @default.
• W2001193188 hasAuthorship W2001193188A5070449635 @default.
• W2001193188 hasAuthorship W2001193188A5071830752 @default.
• W2001193188 hasBestOaLocation W20011931881 @default.
• W2001193188 hasConcept C104317684 @default.
• W2001193188 hasConcept C112952253 @default.
• W2001193188 hasConcept C134935766 @default.
• W2001193188 hasConcept C150194340 @default.
• W2001193188 hasConcept C153911025 @default.
• W2001193188 hasConcept C161223559 @default.
• W2001193188 hasConcept C167227067 @default.
• W2001193188 hasConcept C183873130 @default.
• W2001193188 hasConcept C190062978 @default.
• W2001193188 hasConcept C2780751114 @default.
• W2001193188 hasConcept C49805395 @default.
• W2001193188 hasConcept C54355233 @default.
• W2001193188 hasConcept C67705224 @default.
• W2001193188 hasConcept C68592252 @default.
• W2001193188 hasConcept C80828422 @default.
• W2001193188 hasConcept C86803240 @default.
• W2001193188 hasConceptScore W2001193188C104317684 @default.
• W2001193188 hasConceptScore W2001193188C112952253 @default.
• W2001193188 hasConceptScore W2001193188C134935766 @default.
• W2001193188 hasConceptScore W2001193188C150194340 @default.
• W2001193188 hasConceptScore W2001193188C153911025 @default.
• W2001193188 hasConceptScore W2001193188C161223559 @default.
• W2001193188 hasConceptScore W2001193188C167227067 @default.
• W2001193188 hasConceptScore W2001193188C183873130 @default.
• W2001193188 hasConceptScore W2001193188C190062978 @default.

• next