FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001194276> ?p ?o ?g. }

• W2001194276 endingPage "509" @default.
• W2001194276 startingPage "499" @default.
• W2001194276 abstract "Background Nanoemulsions are broadly antimicrobial oil-in-water emulsions containing nanometer-sized droplets stabilized with surfactants. We hypothesize that topical application of a nanoemulsion compound (NB-201) can attenuate burn wound infection. In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and thereby lessen inflammation following thermal injury. Methods Male Sprague-Dawley rats underwent a 20% total body surface area scald burn to create a partial-thickness burn injury. Animals were resuscitated with Ringer's lactate solution and the wound covered with an occlusive dressing. At 8 hours after injury, the burn wound was inoculated with 1 × 106 colony-forming units (CFUs) of Pseudomonas aeruginosa. NB-201, NB-201 placebo, 5% mafenide acetate solution, or 0.9% saline (control) was applied onto the wound at 16 and 24 hours after burn injury. Skin was harvested 32 hours postburn for quantitative wound culture and determination of inflammatory mediators in tissue homogenates. Results NB-201 decreased mean bacterial growth in the burn wound by 1,000-fold, with only 13% (3/23) of animals having P. aeruginosa counts greater than 105 CFU/g tissue versus 91% (29/32) in the control group (P < .0001). Treatment with NB-201 attenuated neutrophil sequestration in the treatment group as measured by myeloperoxidase assay and by histology. It also significantly decreased levels of proinflammatory cytokines (interleukin [IL]-1β and IL-6) and the degree of hair follicle cell apoptosis in skin compared to saline-treated controls. Conclusion Topical NB-201 substantially decreased bacterial growth in a partial-thickness burn model. This decrease in the level of wound infection was associated with an attenuation of the local dermal inflammatory response and diminished neutrophil sequestration. NB-201 represents a novel potent antimicrobial and anti-inflammatory treatment for use in burn wounds. Nanoemulsions are broadly antimicrobial oil-in-water emulsions containing nanometer-sized droplets stabilized with surfactants. We hypothesize that topical application of a nanoemulsion compound (NB-201) can attenuate burn wound infection. In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and thereby lessen inflammation following thermal injury. Male Sprague-Dawley rats underwent a 20% total body surface area scald burn to create a partial-thickness burn injury. Animals were resuscitated with Ringer's lactate solution and the wound covered with an occlusive dressing. At 8 hours after injury, the burn wound was inoculated with 1 × 106 colony-forming units (CFUs) of Pseudomonas aeruginosa. NB-201, NB-201 placebo, 5% mafenide acetate solution, or 0.9% saline (control) was applied onto the wound at 16 and 24 hours after burn injury. Skin was harvested 32 hours postburn for quantitative wound culture and determination of inflammatory mediators in tissue homogenates. NB-201 decreased mean bacterial growth in the burn wound by 1,000-fold, with only 13% (3/23) of animals having P. aeruginosa counts greater than 105 CFU/g tissue versus 91% (29/32) in the control group (P < .0001). Treatment with NB-201 attenuated neutrophil sequestration in the treatment group as measured by myeloperoxidase assay and by histology. It also significantly decreased levels of proinflammatory cytokines (interleukin [IL]-1β and IL-6) and the degree of hair follicle cell apoptosis in skin compared to saline-treated controls. Topical NB-201 substantially decreased bacterial growth in a partial-thickness burn model. This decrease in the level of wound infection was associated with an attenuation of the local dermal inflammatory response and diminished neutrophil sequestration. NB-201 represents a novel potent antimicrobial and anti-inflammatory treatment for use in burn wounds." @default.
• W2001194276 created "2016-06-24" @default.
• W2001194276 creator A5013132932 @default.
• W2001194276 creator A5034045203 @default.
• W2001194276 creator A5041311658 @default.
• W2001194276 creator A5042901119 @default.
• W2001194276 creator A5042966626 @default.
• W2001194276 creator A5067352062 @default.
• W2001194276 creator A5070696061 @default.
• W2001194276 creator A5071938937 @default.
• W2001194276 date "2010-09-01" @default.
• W2001194276 modified "2023-10-12" @default.
• W2001194276 title "Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury" @default.
• W2001194276 cites W1491638863 @default.
• W2001194276 cites W1934306908 @default.
• W2001194276 cites W1966109013 @default.
• W2001194276 cites W1972874692 @default.
• W2001194276 cites W1979880702 @default.
• W2001194276 cites W1980221110 @default.
• W2001194276 cites W2002740429 @default.
• W2001194276 cites W2003075322 @default.
• W2001194276 cites W2010762616 @default.
• W2001194276 cites W2033439777 @default.
• W2001194276 cites W2049602205 @default.
• W2001194276 cites W2083311051 @default.
• W2001194276 cites W2083717866 @default.
• W2001194276 cites W2089096428 @default.
• W2001194276 cites W2099113508 @default.
• W2001194276 cites W2114425952 @default.
• W2001194276 cites W2140350928 @default.
• W2001194276 cites W2140934543 @default.
• W2001194276 cites W2169079319 @default.
• W2001194276 cites W2171361469 @default.
• W2001194276 doi "https://doi.org/10.1016/j.surg.2010.01.001" @default.
• W2001194276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2891388" @default.
• W2001194276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20189619" @default.
• W2001194276 hasPublicationYear "2010" @default.
• W2001194276 type Work @default.
• W2001194276 sameAs 2001194276 @default.
• W2001194276 citedByCount "71" @default.
• W2001194276 countsByYear W20011942762012 @default.
• W2001194276 countsByYear W20011942762013 @default.
• W2001194276 countsByYear W20011942762014 @default.
• W2001194276 countsByYear W20011942762015 @default.
• W2001194276 countsByYear W20011942762016 @default.
• W2001194276 countsByYear W20011942762017 @default.
• W2001194276 countsByYear W20011942762018 @default.
• W2001194276 countsByYear W20011942762019 @default.
• W2001194276 countsByYear W20011942762020 @default.
• W2001194276 countsByYear W20011942762021 @default.
• W2001194276 countsByYear W20011942762022 @default.
• W2001194276 countsByYear W20011942762023 @default.
• W2001194276 crossrefType "journal-article" @default.
• W2001194276 hasAuthorship W2001194276A5013132932 @default.
• W2001194276 hasAuthorship W2001194276A5034045203 @default.
• W2001194276 hasAuthorship W2001194276A5041311658 @default.
• W2001194276 hasAuthorship W2001194276A5042901119 @default.
• W2001194276 hasAuthorship W2001194276A5042966626 @default.
• W2001194276 hasAuthorship W2001194276A5067352062 @default.
• W2001194276 hasAuthorship W2001194276A5070696061 @default.
• W2001194276 hasAuthorship W2001194276A5071938937 @default.
• W2001194276 hasBestOaLocation W20011942762 @default.
• W2001194276 hasConcept C141071460 @default.
• W2001194276 hasConcept C164027704 @default.
• W2001194276 hasConcept C185592680 @default.
• W2001194276 hasConcept C203014093 @default.
• W2001194276 hasConcept C203565725 @default.
• W2001194276 hasConcept C2776782833 @default.
• W2001194276 hasConcept C2776914184 @default.
• W2001194276 hasConcept C2777192170 @default.
• W2001194276 hasConcept C2777397205 @default.
• W2001194276 hasConcept C2777637488 @default.
• W2001194276 hasConcept C2780269544 @default.
• W2001194276 hasConcept C2993242423 @default.
• W2001194276 hasConcept C3019879682 @default.
• W2001194276 hasConcept C31903555 @default.
• W2001194276 hasConcept C42219234 @default.
• W2001194276 hasConcept C523546767 @default.
• W2001194276 hasConcept C54355233 @default.
• W2001194276 hasConcept C71924100 @default.
• W2001194276 hasConcept C86803240 @default.
• W2001194276 hasConcept C98274493 @default.
• W2001194276 hasConceptScore W2001194276C141071460 @default.
• W2001194276 hasConceptScore W2001194276C164027704 @default.
• W2001194276 hasConceptScore W2001194276C185592680 @default.
• W2001194276 hasConceptScore W2001194276C203014093 @default.
• W2001194276 hasConceptScore W2001194276C203565725 @default.
• W2001194276 hasConceptScore W2001194276C2776782833 @default.
• W2001194276 hasConceptScore W2001194276C2776914184 @default.
• W2001194276 hasConceptScore W2001194276C2777192170 @default.
• W2001194276 hasConceptScore W2001194276C2777397205 @default.
• W2001194276 hasConceptScore W2001194276C2777637488 @default.
• W2001194276 hasConceptScore W2001194276C2780269544 @default.
• W2001194276 hasConceptScore W2001194276C2993242423 @default.
• W2001194276 hasConceptScore W2001194276C3019879682 @default.
• W2001194276 hasConceptScore W2001194276C31903555 @default.
• W2001194276 hasConceptScore W2001194276C42219234 @default.
• W2001194276 hasConceptScore W2001194276C523546767 @default.

• next