FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001197023> ?p ?o ?g. }

• W2001197023 endingPage "406" @default.
• W2001197023 startingPage "405" @default.
• W2001197023 abstract "Limited attention has been devoted to the differential diagnosis of neurological/psychiatric disturbances in cirrhosis. Therefore, there is a risk that in these patients virtually any neurological/psychiatric abnormality will be considered, by default, to be due to hepatic encephalopathy (HE).1 We run a daily HE clinic, to which patients are referred for evaluation of diagnosed/suspected HE, or for pretransplant screening. Our evaluation includes laboratory tests (full blood count, liver/kidney function, electrolytes, venous ammonia, thyroid stimulating hormone [TSH], C-reactive protein [CRP], and vitamin B12), examination by a physician and a neuropsychologist, a comprehensive set of neuropsychological tests, critical flicker frequency (CFF), and electroencephalography (EEG). If needed, cerebral imaging and/or repeat evaluations after the institution of appropriate treatment are performed. A final diagnosis is reached after joint review of patient history and all tests, taking into account the known features of the HE profile (i.e., impairment of psychomotor speed, attention, executive function and inhibition, with relatively preserved memory, slowed EEG, low CFF, and high ammonia levels). Between June 2009 and May 2013, we evaluated 276 patients (94% outpatients; 200 males, age 58 ± 11 years, Child-Pugh A 37%, B 41%, C 22%, Model for Endstage Liver Disease [MELD] 13 ± 6), 61 of whom were seen more than once. Of the 276, 99 (36%) were neuropsychiatrically unimpaired; 90 (33%) had clinically obvious neurological/psychiatric abnormalities and 87 (32%) had subclinical abnormalities (neuropsychological and/or EEG and/or CFF). Of 90 patients with overt abnormalities, 35 were deemed to have HE and 55 had other comorbidities that could contribute or fully explain their neurological/psychiatric profiles (Fig. 1). Of 87 patients with subclinical abnormalities, 47 were deemed to have minimal HE and 40 had comorbidities that could contribute or fully explain their profiles. Thus, 95/177 patients (54%) with overt or subclinical alterations had comorbidities other than HE that could contribute to these alterations. Comorbidities and confounders included recent alcohol misuse (n = 15), cerebrovascular disease (17), malnutrition (6), severe hyponatremia (2) or hypoglycemia (1), hypothyroidism (2), infection/sepsis (5), psychoactive drugs (4), and various combinations of the above in a single patient. Several of these comorbidities are unlikely to benefit from a new liver. Patients with comorbidities/confounders were significantly older than those without (59.8 ± 10.8 versus 56.8 ± 11.5 years, P = 0.04). Short, stand-alone tests for HE diagnosis such as CFF, brief sets of questions, and quick computerized tests have long been advocated for use in the clinic or at the bedside, and may be adequate for screening purposes. However, considerably more comprehensive evaluations seem necessary as a second step, especially for patients on a transplant list. In the same way as we do not expect an ECG, an echocardiogram, or an angiogram to provide us with comprehensive information on cardiac function as stand-alone tests, we should not expect one test to provide us with comprehensive information on cerebral function in cirrhosis. It is our impression that for the time being the HE quick diagnosis remains fiction, and the specificity of any neurological/psychiatric test a myth. Sara Montagnese, Ph.D. Sami Schiff, Ph.D. Piero Amodio, M.D. Department of Medicine University of Padova Italy" @default.
• W2001197023 created "2016-06-24" @default.
• W2001197023 creator A5001792300 @default.
• W2001197023 creator A5012973759 @default.
• W2001197023 creator A5060763428 @default.
• W2001197023 date "2014-05-12" @default.
• W2001197023 modified "2023-09-27" @default.
• W2001197023 title "Quick diagnosis of hepatic encephalopathy: Fact or fiction?" @default.
• W2001197023 cites W2026352845 @default.
• W2001197023 cites W2059793730 @default.
• W2001197023 cites W2091213918 @default.
• W2001197023 doi "https://doi.org/10.1002/hep.27127" @default.
• W2001197023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24623335" @default.
• W2001197023 hasPublicationYear "2014" @default.
• W2001197023 type Work @default.
• W2001197023 sameAs 2001197023 @default.
• W2001197023 citedByCount "9" @default.
• W2001197023 countsByYear W20011970232015 @default.
• W2001197023 countsByYear W20011970232017 @default.
• W2001197023 countsByYear W20011970232018 @default.
• W2001197023 countsByYear W20011970232019 @default.
• W2001197023 countsByYear W20011970232021 @default.
• W2001197023 countsByYear W20011970232022 @default.
• W2001197023 countsByYear W20011970232023 @default.
• W2001197023 crossrefType "journal-article" @default.
• W2001197023 hasAuthorship W2001197023A5001792300 @default.
• W2001197023 hasAuthorship W2001197023A5012973759 @default.
• W2001197023 hasAuthorship W2001197023A5060763428 @default.
• W2001197023 hasBestOaLocation W20011970231 @default.
• W2001197023 hasConcept C113280763 @default.
• W2001197023 hasConcept C118552586 @default.
• W2001197023 hasConcept C126322002 @default.
• W2001197023 hasConcept C14216870 @default.
• W2001197023 hasConcept C142724271 @default.
• W2001197023 hasConcept C169900460 @default.
• W2001197023 hasConcept C187212893 @default.
• W2001197023 hasConcept C2777075537 @default.
• W2001197023 hasConcept C2777214474 @default.
• W2001197023 hasConcept C2778621155 @default.
• W2001197023 hasConcept C2780168130 @default.
• W2001197023 hasConcept C2780325230 @default.
• W2001197023 hasConcept C2780801072 @default.
• W2001197023 hasConcept C2781099255 @default.
• W2001197023 hasConcept C2992208098 @default.
• W2001197023 hasConcept C512861765 @default.
• W2001197023 hasConcept C522805319 @default.
• W2001197023 hasConcept C71924100 @default.
• W2001197023 hasConceptScore W2001197023C113280763 @default.
• W2001197023 hasConceptScore W2001197023C118552586 @default.
• W2001197023 hasConceptScore W2001197023C126322002 @default.
• W2001197023 hasConceptScore W2001197023C14216870 @default.
• W2001197023 hasConceptScore W2001197023C142724271 @default.
• W2001197023 hasConceptScore W2001197023C169900460 @default.
• W2001197023 hasConceptScore W2001197023C187212893 @default.
• W2001197023 hasConceptScore W2001197023C2777075537 @default.
• W2001197023 hasConceptScore W2001197023C2777214474 @default.
• W2001197023 hasConceptScore W2001197023C2778621155 @default.
• W2001197023 hasConceptScore W2001197023C2780168130 @default.
• W2001197023 hasConceptScore W2001197023C2780325230 @default.
• W2001197023 hasConceptScore W2001197023C2780801072 @default.
• W2001197023 hasConceptScore W2001197023C2781099255 @default.
• W2001197023 hasConceptScore W2001197023C2992208098 @default.
• W2001197023 hasConceptScore W2001197023C512861765 @default.
• W2001197023 hasConceptScore W2001197023C522805319 @default.
• W2001197023 hasConceptScore W2001197023C71924100 @default.
• W2001197023 hasIssue "1" @default.
• W2001197023 hasLocation W20011970231 @default.
• W2001197023 hasLocation W20011970232 @default.
• W2001197023 hasOpenAccess W2001197023 @default.
• W2001197023 hasPrimaryLocation W20011970231 @default.
• W2001197023 hasRelatedWork W119022703 @default.
• W2001197023 hasRelatedWork W128282129 @default.
• W2001197023 hasRelatedWork W2015243077 @default.
• W2001197023 hasRelatedWork W2060619081 @default.
• W2001197023 hasRelatedWork W2085106099 @default.
• W2001197023 hasRelatedWork W2351914033 @default.
• W2001197023 hasRelatedWork W2374267285 @default.
• W2001197023 hasRelatedWork W2406751081 @default.
• W2001197023 hasRelatedWork W2978341149 @default.
• W2001197023 hasRelatedWork W3029505026 @default.
• W2001197023 hasVolume "61" @default.
• W2001197023 isParatext "false" @default.
• W2001197023 isRetracted "false" @default.
• W2001197023 magId "2001197023" @default.
• W2001197023 workType "article" @default.