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• W2001204396 endingPage "e110958" @default.
• W2001204396 startingPage "e110958" @default.
• W2001204396 abstract "The centrosome cycle is most often coordinated with mitotic cell division through the activity of various essential cell cycle regulators, consequently ensuring that the centriole is duplicated once, and only once, per cell cycle. However, this coupling can be altered in specific developmental contexts; for example, multi-ciliated cells generate hundreds of centrioles without any S-phase requirement for their biogenesis, while Drosophila follicle cells eliminate their centrosomes as they begin to endoreduplicate. In order to better understand how the centrosome cycle and the cell cycle are coordinated in a developmental context we use the endoreduplicating intestinal cell lineage of C. elegans to address how novel variations of the cell cycle impact this important process. In C. elegans, the larval intestinal cells undergo one nuclear division without subsequent cytokinesis, followed by four endocycles that are characterized by successive rounds of S-phase. We monitored the levels of centriolar/centrosomal markers and found that centrosomes lose their pericentriolar material following the nuclear division that occurs during the L1 stage and is thereafter never re-gained. The centrioles then become refractory to S phase regulators that would normally promote duplication during the first endocycle, after which they are eliminated during the L2 stage. Furthermore, we show that SPD-2 plays a central role in the numeral regulation of centrioles as a potential target of CDK activity. On the other hand, the phosphorylation on SPD-2 by Polo-like kinase, the transcriptional regulation of genes that affect centriole biogenesis, and the ubiquitin/proteasome degradation pathway, contribute collectively to the final elimination of the centrioles during the L2 stage." @default.
• W2001204396 created "2016-06-24" @default.
• W2001204396 creator A5072214197 @default.
• W2001204396 creator A5086269163 @default.
• W2001204396 date "2014-10-31" @default.
• W2001204396 modified "2023-09-25" @default.
• W2001204396 title "Centrosome/Cell Cycle Uncoupling and Elimination in the Endoreduplicating Intestinal Cells of C. elegans" @default.
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• W2001204396 doi "https://doi.org/10.1371/journal.pone.0110958" @default.
• W2001204396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4215990" @default.
• W2001204396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25360893" @default.
• W2001204396 hasPublicationYear "2014" @default.
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