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• W2001231008 abstract "<b><i>Background:</i></b> Autoimmunity is considered an uncommon but under-recognised cause of cognitive decline. <b><i>Methods:</i></b> Serum samples from 3,253 randomly selected subjects enrolled in the Hunter Community Study, aged 55-85 years, were assayed for thyrotropin stimulatory hormone, anti-thyroid peroxidase antibodies (TPO-Ab), anti-nuclear antibodies (ANA) and extractable nuclear antigens (ENA). Cognitive function was assessed using the Audio Recorded Cognitive Screen (ARCS) tool. <b><i>Results:</i></b> TPO-Ab were found in 8.4% and ANA in 27.9% of the study population, of whom 3% had positive ENA findings. No relationship was found between the ARCS score and either TPO-Ab (coefficient = 0.133; 95% CI -0.20, 0.82, p = 0.616), ANA at a low (coefficient = 1.01; 95% CI -2.58, 0.55, p = 0.203) or a high titre (coefficient = -0.65; 95% CI -2.59, 1.28, p = 0.508), or ENA antibodies (coefficient = 5.12; 95% CI -0.53, 10.77; p = 0.076). <b><i>Conclusions:</i></b> Autoantibody findings are common in an aging population and are not associated with cognitive decline." @default.
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• W2001231008 date "2014-05-21" @default.
• W2001231008 modified "2023-09-25" @default.
• W2001231008 title "Thyroid Antibodies, Autoimmunity and Cognitive Decline: Is There a Population-Based Link" @default.
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• W2001231008 doi "https://doi.org/10.1159/000362716" @default.
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