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- W2001231209 abstract "Cilia are evolutionarily conserved organelles found on many mammalian cell types, including neuronal populations. Although neuronal cilia, including those on olfactory sensory neurons (OSNs), are often delineated by localization of adenylyl cyclase 3 (AC3, also known as ADCY3), the mechanisms responsible for targeting integral membrane proteins are largely unknown. Post-translational modification by small ubiquitin-like modifier (SUMO) proteins plays an important role in protein localization processes such as nuclear-cytosolic transport. Here, we identified through bioinformatic analysis that adenylyl cyclases harbor conserved SUMOylation motifs, and show that AC3 is a substrate for SUMO modification. Functionally, overexpression of the SUMO protease SENP2 prevented ciliary localization of AC3, without affecting ciliation or cilia maintenance. Furthermore, AC3-SUMO mutants did not localize to cilia. To test whether SUMOylation is sufficient for cilia entry, we compared localization of ANO2, which possesses a SUMO motif, and ANO1, which lacks SUMOylation sites and does not localize to cilia. Introduction of SUMOylation sites into ANO1 was not sufficient for ciliary entry. These data suggest that SUMOylation is necessary but not sufficient for ciliary trafficking of select constituents, further establishing the link between ciliary and nuclear import." @default.
- W2001231209 created "2016-06-24" @default.
- W2001231209 creator A5000099650 @default.
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- W2001231209 creator A5062729464 @default.
- W2001231209 date "2015-05-15" @default.
- W2001231209 modified "2023-10-17" @default.
- W2001231209 title "SUMOylation regulates ciliary localization of olfactory signaling proteins" @default.
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- W2001231209 doi "https://doi.org/10.1242/jcs.164673" @default.
- W2001231209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4457158" @default.
- W2001231209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25908845" @default.
- W2001231209 hasPublicationYear "2015" @default.
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