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• W2001231846 abstract "Tissue transglutaminase (tTG) has a high affinity for fibronectin (FN) and is a coreceptor of both beta1 and beta3 integrin subunits. Considering the notion that FN and integrins have critical roles during the implantation process, this study was undertaken to elucidate the expression pattern and the potential physiological function of tTG at the embryo-maternal interface.The primary cultures of human placentas from 15 legal elective abortions at the first trimester of normal pregnancies and endometrial biopsies of 12 female patients in the midluteal phase as well as normal trophoblastic cell lines (CRL) were employed to address these issues using several approaches, such as scanning and transmission electron microscopies, immunostaining for light and electron microscopies, western blotting, and function assays using GRGDSP hexapeptide and an antibody against tTG.The results demonstrated tTG expression on uterine pinopodes and lamellipodia of extravillous trophoblasts. The colocalization of tTG with beta1 and beta3 integrins and its interaction with alpha(v)beta3 integrin and integrin-associated proteins at focal adhesions of the extravillous trophoblasts were illustrated in the results of immunofluorescence, immunoblot, and coimmunoprecipitation studies. Furthermore, function assays revealed that tTG mediated the adhesion and spread of the placental cells on intact FN-coated and 42- and 110-kDa FN fragment-coated wells.In conclusion, our findings demonstrated for the first time that tTG actively participates in adhesion events at the embryo-maternal interface through its interaction with FN, at least in part, by activating integrin-signaling pathways." @default.
• W2001231846 created "2016-06-24" @default.
• W2001231846 creator A5005171861 @default.
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• W2001231846 creator A5037820158 @default.
• W2001231846 creator A5065345187 @default.
• W2001231846 creator A5085092050 @default.
• W2001231846 date "2005-08-01" @default.
• W2001231846 modified "2023-10-18" @default.
• W2001231846 title "Tissue Transglutaminase at Embryo-Maternal Interface" @default.
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• W2001231846 doi "https://doi.org/10.1210/jc.2005-0240" @default.
• W2001231846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15886239" @default.
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