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- W2001232449 abstract "The cytotoxic plant alkaloid palmatine was found to bind strongly by partial intercalation to single stranded poly(A) structure with binding affinity (Ka) of (8.36 ± 0.26) × 105 M−1. The binding of palmatine was characterized to be exothermic and enthalpy driven with one palmatine for every two adenine residues. On the other hand, the binding to the double stranded poly(A) has been found to be significantly weak. This study identifies poly(A) as a potential bio-target for the alkaloid palmatine and its use as a lead compound in antitumor drug screening." @default.
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- W2001232449 date "2006-05-01" @default.
- W2001232449 modified "2023-09-28" @default.
- W2001232449 title "RNA specific molecules: Cytotoxic plant alkaloid palmatine binds strongly to poly(A)" @default.
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- W2001232449 doi "https://doi.org/10.1016/j.bmcl.2006.01.124" @default.
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