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- W2001232845 abstract "Abstract The effect of acute treatment with MK-771, a thyrotropin-releasing hormone analog, has been investigated on the synthesis and release of dopamine and 5-hydroxytryptamine in rat brain. Single injection of MK-771 in doses of 10 and 15 mg/kg produced a rise in tyrosine hydroxylase activity as well as homovanillic acid level in striatum (a site of nigrostriatal dopamine system) and olfactory tubercles (a site of mesolimbic dopamine system). The dopamine levels remained unchanged (olfactory tubercles, hippocampus) or decreased (striatum, hypothalamus, pons-medulla) after MK-771 treatment. Acute MK-771 injection at the dose of 15 mg/kg increased mid-brain tryptophan hydroxylase activity and tryptophan levels by 26% and 55%, respectively. A consistent increase in the levels of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid was reported in several brain areas. These data suggest that MK-771 elicits a marked increase in the synthesis and turnover of brain dopamine and 5-hydroxytryptamine." @default.
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- W2001232845 date "1981-08-01" @default.
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- W2001232845 title "Effects of MK-771, a novel TRH analog, on brain dopaminergic and serotonergic systems" @default.
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- W2001232845 doi "https://doi.org/10.1016/0014-2999(81)90231-4" @default.
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