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• W2001232960 abstract "No AccessJournal of UrologyPediatric Urology1 Aug 2004EPIDEMIOLOGICAL AND CLINICAL BEHAVIOR OF PREPUBERTAL TESTICULAR TUMORS IN KOREA SANG DON LEE and KOREAN SOCIETY OF PEDIATRIC UROLOGY SANG DON LEESANG DON LEE More articles by this author and KOREAN SOCIETY OF PEDIATRIC UROLOGY More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000129571.13955.6bAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To our knowledge there is no multi-institutional report on prepubertal testicular tumors in Korea to date. We obtained demographic data for a better understanding of the biological behavior and optimal management of these tumors. Materials and Methods: The prepubertal testicular tumor registry form was mailed to all 87 hospitals registered in the Korean Urology Association. We retrospectively reviewed recent 5-year medical records. Results: A total of 209 patients were enrolled in this registry. The incidence was 0.98/100,000 children. Age was 1 to 142 months (median 18). Most patients were diagnosed with a scrotal mass before age 4 years. Serum α-fetoprotein and β-human chorionic gonadotropin increased in as many as 62.9% and 2.7% of patients, including 94.7% and 2.2% in those with yolk sac tumor and 30.4% and 2.7% in those with teratoma, respectively. While potentially malignant tumors accounted for 52.5% of patients, the remainder were benign. Germ cell tumors were the most common (89.4% of cases), mainly with yolk sac tumor (47.8%) or teratoma (39.7%). Management after surgery included surveillance in 71.8% of cases, chemotherapy in 9.1%, combination therapy in 1.4% and other in 17.7%. Of the total patients 10.5% (5.9% of stage I yolk sac tumors) had progression to metastasis. The final results of treatment were complete remission (64.6% of cases), incomplete remission (2.9%), no response or disease progression (1.4%) and unknown (31.1%). Outcomes at the last followup (average 23.5 months) were 76.1% of patients alive, 0.9% dead and 23.0% of unknown status. Conclusions: Demographic data on pediatric testicular tumors in Korea will lead to a better understanding of these rare tumors and to optimal therapy in these children. References 1 : Testicular tumors in prepubertal children. Urology1979; 13: 581. Google Scholar 2 : Prepubertal yolk sac testicular tumors—report of the testicular tumor registry. J Urol1988; 140: 1109. Link, Google Scholar 3 : Prepubertal testicular tumor registry. J Urol1993; 150: 671. Link, Google Scholar 4 : Testicular and paratesticular tumours in children: 30 years’ experience. Aust N Z J Surg1999; 69: 505. Google Scholar 5 : Two decades of experience with testicular tumors in children at St Jude Children’s Research Hospital. J Pediatr Surg1989; 24: 677. Google Scholar 6 : Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the Prepubertal Testis Tumor Registry. J Urol2002; 168: 1675. Link, Google Scholar 7 : Pediatric testicular tumors: contemporary incidence and efficacy of testicular preserving surgery. J Urol2003; 170: 2412. Link, Google Scholar 8 : Testis-sparing surgery for benign testicular tumors in children. J Urol2001; 165: 2280. Link, Google Scholar 9 : Introduction. In: Pediatrics. Edited by . Seoul: Daehan Printing and Publishing Co., Ltd.2001: 15. Google Scholar 10 Available at http://www.nso.go.kr/cgi-bin/sws_999.cgi. Accessed January, 2004 Google Scholar 11 : Pediatric oncology. In: . Philadelphia: W. B. Saunders Co.1998: 2245. chapt. 74, sect. IX. Google Scholar 12 : Testicular tumors. In: Pediatric Urology. Edited by . Oxford: Butterworth-Heinemann1997: 756. Google Scholar 13 : Testicular tumors in childhood. J Pediatr Surg1975; 10: 109. Google Scholar 14 : Melanotic neuroectodermal tumor of the epididymis in infancy: case report and review of the literature. Urology1995; 46: 415. Google Scholar 15 : Melanotic neuroectodermal tumor of infancy. A reexamination of a histogenetic problem based on immunohistochemical, flow cytometric, and ultrastructural study of 10 cases. Am J Surg Pathol1991; 15: 233. Google Scholar From the Department of Urology, College of Medicine, Pusan National University, Busan, Korea© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 172Issue 2August 2004Page: 674-678 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordstestisregistriestesticular neoplasmsquestionnairesKoreaMetricsAuthor Information SANG DON LEE More articles by this author KOREAN SOCIETY OF PEDIATRIC UROLOGY More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2001232960 title "EPIDEMIOLOGICAL AND CLINICAL BEHAVIOR OF PREPUBERTAL TESTICULAR TUMORS IN KOREA" @default.
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