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- W2001242302 abstract "Topical nuclear magnetic resonance allows non-invasive investigation of the metabolism of skeletal muscle and other tissues. Energy exchange can be followed by measurement of 31P NMR spectra which characterise changes in muscle content of inorganic phosphorus (Pi) and phosphorylcreatine. Muscle pH is determined from the chemical shift of Pi with respect to phosphorylcreatine. Topical NMR can be used to study changes in intermediary metabolites during exercise, and the clinical value is illustrated in a patient with phosphofructokinase deficiency who would otherwise have required multiple biopsies of muscle. In diseases such as Duchenne muscular dystrophy, where muscle may be partly replaced by fat or other tissue, the findings with 31P NMR can be related to independent estimates of tissue composition obtained from 1H and 13C NMR spectra and from X-ray computerised tomography." @default.
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- W2001242302 date "1982-03-01" @default.
- W2001242302 modified "2023-10-15" @default.
- W2001242302 title "CLINICAL USE OF NUCLEAR MAGNETIC RESONANCE IN THE INVESTIGATION OF MYOPATHY" @default.
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- W2001242302 doi "https://doi.org/10.1016/s0140-6736(82)92635-6" @default.
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