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• W2001242945 abstract "Injection of adrenalectomized, fasted rats with cortisol, corticosterone and deoxycorticosterone reduces the net glucose uptake by subsequently isolated epididymal adipose tissue. Deoxycorticosterone is less active than the other two compounds, which are about equally active. The effect can be observed within 30 min of injection. Normal rats, fed or fasted, and hypophysectomized, adrenalectomized rats respond in the same way. The same steroids in vitro have similar actions, with relative activities comparable to those displayedin vivo. Significant effects are observed at all concentrations down to 9·10 −8M. Below 10−6M, the effects occur mainly after the incubation has proceeded for 2.5 h. Adipose tissue from alloxan-diabetic, adrenalectomized rats appears to respond in the same way. It is suggested that these findings: (a) account in part for the changes in carbohydrate metabolism which take place during the first hours after injection of rats with glucocorticoids; (b) show that epididymal adipose tissue is a direct target for the action of glucocorticoids; (c) can account qualitatively for the known effects of glucocorticoids on adipose tissue, in particular, for the permissive actions with respect to free fatty acid release. These findings are considered to provide direct evidence in support of the hypothesis that some of the major effects of glucocorticoids on extrahepatic tissues may be secondary to a decrease in glucose utilization." @default.
• W2001242945 created "2016-06-24" @default.
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• W2001242945 date "1962-01-01" @default.
• W2001242945 modified "2023-10-15" @default.
• W2001242945 title "Studies on the mode of action of glucocorticoids in rats II. The effectsin vivo andin vitro on net glucose uptake by isolated adipose tissue" @default.
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• W2001242945 doi "https://doi.org/10.1016/0006-3002(62)91125-3" @default.
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