Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001248841> ?p ?o ?g. }
- W2001248841 endingPage "600" @default.
- W2001248841 startingPage "590" @default.
- W2001248841 abstract "Abstract The immature brain is prone to seizures but the underlying mechanisms are poorly understood. We explored the hypothesis that increased seizure susceptibility during early development is due to the excitatory action of GABA. Using noninvasive extracellular field potential and cell‐attached recordings in CA3 of Sprague‐Dawley rat hippocampal slices, we compared the developmental alterations in three parameters: excitatory actions of GABA, presence of the immature pattern of giant depolarizing potentials (GDPs) and severity of epileptiform activity generated by high potassium. The GABA(A) receptor agonist isoguvacine increased firing of CA3 pyramidal cells in neonatal slices while inhibiting activity in adults. A switch in the GABA(A) signalling from excitation to inhibition occurred at postnatal day (P) 13.5 ± 0.4. Field GDPs were present in the form of spontaneous population bursts until P12.7 ± 0.3. High potassium (8.5 m m ) induced seizure‐like events (SLEs) in 35% of slices at P7–16 (peak at P11.3 ± 0.4), but only interictal activity before and after that age. The GABA(A) receptor antagonist bicuculline reduced the frequency or completely blocked SLEs and induced interictal clonic‐like activity accompanied by a reduction in the frequency but an increase in the amplitude of the population spikes. In slices with interictal activity, bicuculline typically caused a large amplitude interictal clonic‐like activity at all ages; in slices from P5–16 rats it was often preceded by one SLE at the beginning of bicuculline application. These results suggest that, in the immature hippocampus, GABA exerts dual (both excitatory and inhibitory) actions and that the excitatory component in the action of GABA may contribute to increased excitability during early development." @default.
- W2001248841 created "2016-06-24" @default.
- W2001248841 creator A5038265309 @default.
- W2001248841 creator A5041824506 @default.
- W2001248841 creator A5048298627 @default.
- W2001248841 creator A5059480714 @default.
- W2001248841 creator A5061193174 @default.
- W2001248841 creator A5079543792 @default.
- W2001248841 date "2004-01-30" @default.
- W2001248841 modified "2023-10-15" @default.
- W2001248841 title "Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus" @default.
- W2001248841 cites W1489519230 @default.
- W2001248841 cites W1575530593 @default.
- W2001248841 cites W1588629441 @default.
- W2001248841 cites W1668541200 @default.
- W2001248841 cites W1880195515 @default.
- W2001248841 cites W1914170586 @default.
- W2001248841 cites W1920088511 @default.
- W2001248841 cites W1925649505 @default.
- W2001248841 cites W1963936849 @default.
- W2001248841 cites W1963992694 @default.
- W2001248841 cites W1964933128 @default.
- W2001248841 cites W1967861153 @default.
- W2001248841 cites W1970958687 @default.
- W2001248841 cites W1971931358 @default.
- W2001248841 cites W1974914532 @default.
- W2001248841 cites W1976416612 @default.
- W2001248841 cites W1976639286 @default.
- W2001248841 cites W1977695003 @default.
- W2001248841 cites W1984499529 @default.
- W2001248841 cites W1987387089 @default.
- W2001248841 cites W1988012239 @default.
- W2001248841 cites W1992665201 @default.
- W2001248841 cites W1995831678 @default.
- W2001248841 cites W2004795758 @default.
- W2001248841 cites W2006129707 @default.
- W2001248841 cites W2010778669 @default.
- W2001248841 cites W2017791457 @default.
- W2001248841 cites W2025076095 @default.
- W2001248841 cites W2027742741 @default.
- W2001248841 cites W2029815605 @default.
- W2001248841 cites W2034080924 @default.
- W2001248841 cites W2034867646 @default.
- W2001248841 cites W2035006995 @default.
- W2001248841 cites W2035721815 @default.
- W2001248841 cites W2041844713 @default.
- W2001248841 cites W2041868953 @default.
- W2001248841 cites W2042485333 @default.
- W2001248841 cites W2045095925 @default.
- W2001248841 cites W2046964936 @default.
- W2001248841 cites W2049075326 @default.
- W2001248841 cites W2052395418 @default.
- W2001248841 cites W2058698189 @default.
- W2001248841 cites W2060589548 @default.
- W2001248841 cites W2061148748 @default.
- W2001248841 cites W2062565038 @default.
- W2001248841 cites W2063592659 @default.
- W2001248841 cites W2064363302 @default.
- W2001248841 cites W2065813782 @default.
- W2001248841 cites W2069586118 @default.
- W2001248841 cites W2071702312 @default.
- W2001248841 cites W2079086000 @default.
- W2001248841 cites W2080726679 @default.
- W2001248841 cites W2083292860 @default.
- W2001248841 cites W2083658603 @default.
- W2001248841 cites W2084712021 @default.
- W2001248841 cites W2088115551 @default.
- W2001248841 cites W2091040471 @default.
- W2001248841 cites W2099711984 @default.
- W2001248841 cites W2113770179 @default.
- W2001248841 cites W2114674389 @default.
- W2001248841 cites W2117770051 @default.
- W2001248841 cites W2120278577 @default.
- W2001248841 cites W2126578880 @default.
- W2001248841 cites W2128273650 @default.
- W2001248841 cites W2131046634 @default.
- W2001248841 cites W2131485187 @default.
- W2001248841 cites W2137730912 @default.
- W2001248841 cites W2145479235 @default.
- W2001248841 cites W2146828561 @default.
- W2001248841 cites W2147827183 @default.
- W2001248841 cites W2160607236 @default.
- W2001248841 cites W2171558421 @default.
- W2001248841 cites W2261008854 @default.
- W2001248841 cites W2418731042 @default.
- W2001248841 cites W2425728667 @default.
- W2001248841 cites W4229806422 @default.
- W2001248841 cites W4297291146 @default.
- W2001248841 cites W4318373852 @default.
- W2001248841 cites W4322701228 @default.
- W2001248841 doi "https://doi.org/10.1111/j.0953-816x.2003.03152.x" @default.
- W2001248841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14984409" @default.
- W2001248841 hasPublicationYear "2004" @default.
- W2001248841 type Work @default.
- W2001248841 sameAs 2001248841 @default.
- W2001248841 citedByCount "292" @default.
- W2001248841 countsByYear W20012488412012 @default.
- W2001248841 countsByYear W20012488412013 @default.