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• W2001252937 abstract "The mle(napts) mutation causes temperature-dependent blockade of action potentials resulting from decreased abundance of para-encoded Na+ channels. Although maleless (mle) encodes a double-stranded RNA (dsRNA) helicase, exactly how mle(napts) affects para expression remained uncertain. Here, we show that para transcripts undergo adenosine-to-inosine (A-to-I) RNA editing via a mechanism that apparently requires dsRNA secondary structure formation encompassing the edited exon and the downstream intron. In an mle(napts) background, >80% of para transcripts are aberrant, owing to internal deletions that include the edited exon. We propose that the Mle helicase is required to resolve the dsRNA structure and that failure to do so in an mle(napts) background causes exon skipping because the normal splice donor is occluded. These results explain how mlen(napts) affects Na+ channel expression and provide new insights into the mechanism of RNA editing." @default.
• W2001252937 created "2016-06-24" @default.
• W2001252937 creator A5007225561 @default.
• W2001252937 creator A5030031056 @default.
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• W2001252937 date "2000-01-01" @default.
• W2001252937 modified "2023-10-18" @default.
• W2001252937 title "The mlenapts RNA Helicase Mutation in Drosophila Results in a Splicing Catastrophe of the para Na + Channel Transcript in a Region of RNA Editing" @default.
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• W2001252937 doi "https://doi.org/10.1016/s0896-6273(00)80878-8" @default.
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