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- W2001260161 abstract "The composition of the typical commercial diet fed to zebrafish can dramatically vary. By utilizing defined diets we sought to answer two questions: 1) How does the embryonic zebrafish transcriptome change when the parental adults are fed a commercial lab diet compared with a sufficient, defined diet (E +)? 2) Does a vitamin E-deficient parental diet (E −) further change the embryonic transcriptome? We conducted a global gene expression study using embryos from zebrafish fed a commercial (Lab), an E + or an E − diet. To capture differentially expressed transcripts prior to onset of overt malformations observed in E − embryos at 48 h post-fertilization (hpf), embryos were collected from each group at 36 hpf. Lab embryos differentially expressed (p < 0.01) 946 transcripts compared with the E + embryos, and 2656 transcripts compared with the E − embryos. The differences in protein, fat and micronutrient intakes in zebrafish fed the Lab compared with the E + diet demonstrate that despite overt morphologic consistency, significant differences in gene expression occurred. Moreover, functional analysis of the significant transcripts in the E − embryos suggested perturbed energy metabolism, leading to overt malformations and mortality. Thus, these findings demonstrate that parental zebrafish diet has a direct impact on the embryonic transcriptome." @default.
- W2001260161 created "2016-06-24" @default.
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- W2001260161 date "2014-06-01" @default.
- W2001260161 modified "2023-10-16" @default.
- W2001260161 title "The influences of parental diet and vitamin E intake on the embryonic zebrafish transcriptome" @default.
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- W2001260161 doi "https://doi.org/10.1016/j.cbd.2014.02.001" @default.
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