Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001261203> ?p ?o ?g. }
- W2001261203 abstract "Significance Communication between nerve cells occurs at specialized cellular structures known as synapses. Loss of synaptic function is associated with cognitive decline in Alzheimer’s disease (AD). However, the mechanism of synaptic damage remains incompletely understood. Here we describe a pathway for synaptic damage whereby amyloid-β 1–42 peptide (Aβ 1–42 ) releases, via stimulation of α7 nicotinic receptors, excessive amounts of glutamate from astrocytes, in turn activating extrasynaptic NMDA-type glutamate receptors (eNMDARs) to mediate synaptic damage. The Food and Drug Administration-approved drug memantine offers some beneficial effect, but the improved eNMDAR antagonist NitroMemantine completely ameliorates Aβ-induced synaptic loss, providing hope for disease-modifying intervention in AD." @default.
- W2001261203 created "2016-06-24" @default.
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- W2001261203 date "2013-06-17" @default.
- W2001261203 modified "2023-10-16" @default.
- W2001261203 title "Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss" @default.
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