FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001262287> ?p ?o ?g. }

• W2001262287 endingPage "1632" @default.
• W2001262287 startingPage "1626" @default.
• W2001262287 abstract "Contrast-enhanced MRI in patients with MS shows that increased permeability of the blood-brain barrier (BBB) commonly occurs. The changes in capillary permeability often precede T2-weighted MRI evidence of tissue damage. In animal studies, intracerebral injection of the matrix metalloproteinase (MMP) 72-kDa type IV collagenase (gelatinase A) opens the BBB by disrupting the basal lamina around capillaries. Steroids affect production of endogenous MMPs and tissue inhibitors to metalloproteinases (TIMPs). To determine the role of MMP activity in BBB damage during acute exacerbations of MS, we measured MMPs in the CSF of patients with MS. Patients (n = 7) given steroids to treat an acute episode of MS had CSF sampled before and after 3 days of methylprednisolone (1 g/day). Patients had a graded neurologic examination and gadolinium-enhanced MRI before treatment. CSF studies included total protein, cell count, and a demyelinating profile. We measured levels of MMPs, urokinase-type plasminogen activator (uPA), and TIMPs by zymography, reverse zymography, and Western blots. The MMP, 92-kDa type IV collagenase (gelatinase B), fell from 216 +/- 70 before steroids to 54 +/- 26 relative lysis zone units (p < 0.046) after treatment. Similarly, uPA dropped from 3880 +/- 800 to 2655 +/- 353 (p < 0.03). Four patients with gadolinium enhancement on MRI had the most pronounced drop in gelatinase B and uPA. Western immunoblots showed an increase in a complex of gelatinase B and TIMPs after treatment, suggesting an increase in a TIMP (p < 0.05). Reverse zymography of CSF samples showed that steroids increased a TIMP with a molecular weight similar to that of mouse TIMP-3 (p = 0.053). Our results suggest that increased gelatinase B is associated with an open BBB on MRI. Steroids may improve capillary function by reducing activity of gelatinase B and uPA and increasing levels of TIMPs." @default.
• W2001262287 created "2016-06-24" @default.
• W2001262287 creator A5001660811 @default.
• W2001262287 creator A5010540807 @default.
• W2001262287 creator A5031525862 @default.
• W2001262287 creator A5055636922 @default.
• W2001262287 creator A5059022626 @default.
• W2001262287 date "1996-06-01" @default.
• W2001262287 modified "2023-09-23" @default.
• W2001262287 title "Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis" @default.
• W2001262287 cites W1508152421 @default.
• W2001262287 cites W1534986377 @default.
• W2001262287 cites W1594236032 @default.
• W2001262287 cites W1968622961 @default.
• W2001262287 cites W1982044334 @default.
• W2001262287 cites W1992220804 @default.
• W2001262287 cites W2001635622 @default.
• W2001262287 cites W2004474896 @default.
• W2001262287 cites W2016202829 @default.
• W2001262287 cites W2034280068 @default.
• W2001262287 cites W2038671895 @default.
• W2001262287 cites W2090345986 @default.
• W2001262287 cites W2098154433 @default.
• W2001262287 cites W2162967708 @default.
• W2001262287 cites W2225456335 @default.
• W2001262287 cites W4211227687 @default.
• W2001262287 doi "https://doi.org/10.1212/wnl.46.6.1626" @default.
• W2001262287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8649561" @default.
• W2001262287 hasPublicationYear "1996" @default.
• W2001262287 type Work @default.
• W2001262287 sameAs 2001262287 @default.
• W2001262287 citedByCount "269" @default.
• W2001262287 countsByYear W20012622872012 @default.
• W2001262287 countsByYear W20012622872013 @default.
• W2001262287 countsByYear W20012622872014 @default.
• W2001262287 countsByYear W20012622872015 @default.
• W2001262287 countsByYear W20012622872016 @default.
• W2001262287 countsByYear W20012622872017 @default.
• W2001262287 countsByYear W20012622872018 @default.
• W2001262287 countsByYear W20012622872019 @default.
• W2001262287 countsByYear W20012622872020 @default.
• W2001262287 countsByYear W20012622872021 @default.
• W2001262287 countsByYear W20012622872022 @default.
• W2001262287 countsByYear W20012622872023 @default.
• W2001262287 crossrefType "journal-article" @default.
• W2001262287 hasAuthorship W2001262287A5001660811 @default.
• W2001262287 hasAuthorship W2001262287A5010540807 @default.
• W2001262287 hasAuthorship W2001262287A5031525862 @default.
• W2001262287 hasAuthorship W2001262287A5055636922 @default.
• W2001262287 hasAuthorship W2001262287A5059022626 @default.
• W2001262287 hasConcept C109523444 @default.
• W2001262287 hasConcept C126322002 @default.
• W2001262287 hasConcept C134018914 @default.
• W2001262287 hasConcept C142724271 @default.
• W2001262287 hasConcept C177430391 @default.
• W2001262287 hasConcept C181199279 @default.
• W2001262287 hasConcept C185592680 @default.
• W2001262287 hasConcept C203014093 @default.
• W2001262287 hasConcept C2776232661 @default.
• W2001262287 hasConcept C2776747403 @default.
• W2001262287 hasConcept C2778394429 @default.
• W2001262287 hasConcept C2778402981 @default.
• W2001262287 hasConcept C2780640218 @default.
• W2001262287 hasConcept C529278444 @default.
• W2001262287 hasConcept C55493867 @default.
• W2001262287 hasConcept C71924100 @default.
• W2001262287 hasConceptScore W2001262287C109523444 @default.
• W2001262287 hasConceptScore W2001262287C126322002 @default.
• W2001262287 hasConceptScore W2001262287C134018914 @default.
• W2001262287 hasConceptScore W2001262287C142724271 @default.
• W2001262287 hasConceptScore W2001262287C177430391 @default.
• W2001262287 hasConceptScore W2001262287C181199279 @default.
• W2001262287 hasConceptScore W2001262287C185592680 @default.
• W2001262287 hasConceptScore W2001262287C203014093 @default.
• W2001262287 hasConceptScore W2001262287C2776232661 @default.
• W2001262287 hasConceptScore W2001262287C2776747403 @default.
• W2001262287 hasConceptScore W2001262287C2778394429 @default.
• W2001262287 hasConceptScore W2001262287C2778402981 @default.
• W2001262287 hasConceptScore W2001262287C2780640218 @default.
• W2001262287 hasConceptScore W2001262287C529278444 @default.
• W2001262287 hasConceptScore W2001262287C55493867 @default.
• W2001262287 hasConceptScore W2001262287C71924100 @default.
• W2001262287 hasIssue "6" @default.
• W2001262287 hasLocation W20012622871 @default.
• W2001262287 hasLocation W20012622872 @default.
• W2001262287 hasOpenAccess W2001262287 @default.
• W2001262287 hasPrimaryLocation W20012622871 @default.
• W2001262287 hasRelatedWork W1976655006 @default.
• W2001262287 hasRelatedWork W1986457921 @default.
• W2001262287 hasRelatedWork W1986890976 @default.
• W2001262287 hasRelatedWork W2045399305 @default.
• W2001262287 hasRelatedWork W2061992885 @default.
• W2001262287 hasRelatedWork W2081362884 @default.
• W2001262287 hasRelatedWork W2106319388 @default.
• W2001262287 hasRelatedWork W4206121514 @default.
• W2001262287 hasRelatedWork W2184999874 @default.
• W2001262287 hasRelatedWork W2742074259 @default.
• W2001262287 hasVolume "46" @default.

• next