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- W2001264593 endingPage "1483" @default.
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- W2001264593 abstract "Solid phase peptide synthesis (SPPS) provides peptides with a dendritic topology when diamino acids are introduced in the sequences. Peptide dendrimers with one to three amino acids between branches can be prepared with up to 38 amino acids (MW ∼ 5,000 Da). Larger peptide dendrimers (MW ∼ 30,000) were obtained by a multivalent chloroacetyl cysteine (ClAc) ligation. Structural studies of peptide dendrimers by CD, FT-IR, NMR and molecular dynamics reveal molten globule states containing up to 50% of α-helix. Esterase and aldolase peptide dendrimers displaying dendritic effects and enzyme kinetics (kcat/kuncat ∼ 105) were designed or discovered by screening large combinatorial libraries. Strong ligands for Pseudomonas aeruginosa lectins LecA and LecB able to inhibit biofilm formation were obtained with glycopeptide dendrimers. Efficient ligands for cobalamin, cytotoxic colchicine conjugates and antimicrobial peptide dendrimers were also developed showing the versatility of dendritic peptides. Complementing the multivalency, the amino acid composition of the dendrimers strongly influenced the catalytic or biological activity obtained demonstrating the importance of the “apple tree” configuration for protein-like function in peptide dendrimers." @default.
- W2001264593 created "2016-06-24" @default.
- W2001264593 creator A5040229188 @default.
- W2001264593 creator A5040848839 @default.
- W2001264593 date "2012-01-01" @default.
- W2001264593 modified "2023-10-02" @default.
- W2001264593 title "Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications" @default.
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- W2001264593 cites W1964929337 @default.
- W2001264593 cites W1965886274 @default.
- W2001264593 cites W1966154824 @default.
- W2001264593 cites W1968869310 @default.
- W2001264593 cites W1976167974 @default.
- W2001264593 cites W1977640142 @default.
- W2001264593 cites W1978654303 @default.
- W2001264593 cites W1985607155 @default.
- W2001264593 cites W1987904724 @default.
- W2001264593 cites W1989135408 @default.
- W2001264593 cites W1992226382 @default.
- W2001264593 cites W1994647184 @default.
- W2001264593 cites W1996192826 @default.
- W2001264593 cites W1999882134 @default.
- W2001264593 cites W2001018320 @default.
- W2001264593 cites W2001614839 @default.
- W2001264593 cites W2002398055 @default.
- W2001264593 cites W2006446936 @default.
- W2001264593 cites W2021667572 @default.
- W2001264593 cites W2022650937 @default.
- W2001264593 cites W2024636746 @default.
- W2001264593 cites W2024787650 @default.
- W2001264593 cites W2026821359 @default.
- W2001264593 cites W2027643568 @default.
- W2001264593 cites W2034067379 @default.
- W2001264593 cites W2036300816 @default.
- W2001264593 cites W2041719513 @default.
- W2001264593 cites W2050895846 @default.
- W2001264593 cites W2052324960 @default.
- W2001264593 cites W2056042508 @default.
- W2001264593 cites W2057568023 @default.
- W2001264593 cites W2059375062 @default.
- W2001264593 cites W2060415984 @default.
- W2001264593 cites W2064923998 @default.
- W2001264593 cites W2066506901 @default.
- W2001264593 cites W2068118045 @default.
- W2001264593 cites W2070466213 @default.
- W2001264593 cites W2072192656 @default.
- W2001264593 cites W2072322889 @default.
- W2001264593 cites W2073706751 @default.
- W2001264593 cites W2077358576 @default.
- W2001264593 cites W2080262597 @default.
- W2001264593 cites W2080575130 @default.
- W2001264593 cites W2081409449 @default.
- W2001264593 cites W2081798331 @default.
- W2001264593 cites W2083456954 @default.
- W2001264593 cites W2083601141 @default.
- W2001264593 cites W2086281152 @default.
- W2001264593 cites W2092095968 @default.
- W2001264593 cites W2096272977 @default.
- W2001264593 cites W2110878830 @default.
- W2001264593 cites W2111432512 @default.
- W2001264593 cites W2113972214 @default.
- W2001264593 cites W2115038320 @default.
- W2001264593 cites W2116139958 @default.
- W2001264593 cites W2116808444 @default.
- W2001264593 cites W2124004334 @default.
- W2001264593 cites W2126067336 @default.
- W2001264593 cites W2128724036 @default.
- W2001264593 cites W2130390690 @default.
- W2001264593 cites W2133084204 @default.
- W2001264593 cites W2134983017 @default.
- W2001264593 cites W2140221090 @default.
- W2001264593 cites W2140658896 @default.
- W2001264593 cites W2140802653 @default.
- W2001264593 cites W2143714577 @default.
- W2001264593 cites W2144852315 @default.
- W2001264593 cites W2145010618 @default.
- W2001264593 cites W2146479681 @default.
- W2001264593 cites W2152181273 @default.
- W2001264593 cites W2160181366 @default.
- W2001264593 cites W2161782568 @default.
- W2001264593 cites W2163323425 @default.
- W2001264593 cites W2164141767 @default.
- W2001264593 cites W2171502090 @default.
- W2001264593 cites W2177178121 @default.
- W2001264593 cites W2325181948 @default.
- W2001264593 cites W2329838504 @default.
- W2001264593 cites W2950238768 @default.
- W2001264593 cites W4210951523 @default.
- W2001264593 cites W4210977178 @default.
- W2001264593 cites W70790455 @default.
- W2001264593 doi "https://doi.org/10.1039/c2ob06938e" @default.
- W2001264593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22274649" @default.
- W2001264593 hasPublicationYear "2012" @default.
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