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- W2001267583 abstract "Somatostatin exerts hormonal and neuroendocrine effects. Since it prevents several organ injuries and systemic intoxications, we tested the hypothesis that activation of Kupffer cells might be one mechanism of the beneficial actions of this peptide. The data presented here demonstrate that somatostatin given i.v. in rats dose- and time-dependently accelerated the clearance of colloidal carbon from the blood and enhanced the uptake of carbon in the liver. On a weight basis, somatostatin was more potent than the RES stimulant zymosan or RES blocker gadolinium chloride. Thus, somatostatin might modulate Kupffer cells and possibly other macrophages, and these effects may have a role in the physiologic or pharmacologic actions of this peptide." @default.
- W2001267583 created "2016-06-24" @default.
- W2001267583 creator A5079679046 @default.
- W2001267583 date "1983-11-01" @default.
- W2001267583 modified "2023-09-26" @default.
- W2001267583 title "Somatostatin stimulates clearance and hepatic uptake of colloidal carbon in the rat" @default.
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- W2001267583 doi "https://doi.org/10.1016/0024-3205(83)90735-x" @default.
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