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• W2001280255 abstract "Inflammation plays a key role in the development and stability of coronary plaques. Endothelial cells alter their expression in response to wall shear stress (WSS). Straight/tubular and asymmetric stenosis models were designed to study the localized expression of atheroprone molecules and inflammatory markers due to the presence of the spatial wall shear stress gradients created by an eccentric plaque. The effects of steady wall shear stress duration (0-24 h) and magnitude (4.5-18 dynes/cm(2)) were analyzed in human abdominal aortic endothelial cells through quantitative real-time polymerase chain reaction (PCR) and immunofluorescence analysis in straight/tubular models. Regional expression was assessed by immunofluorescence and confocal microscopy in stenosis models. Under steady fully developed flow, endothelial cells exhibited a sustained increase in levels of atheroprotective genes with WSS duration and magnitude. The local response in the stenosis model showed that expression of endothelial nitric oxide synthase and Kruppel-like factor 2 is magnitude rather than gradient dependent. A WSS magnitude dependent transient increase in translocation of transcription factor nuclear factor kappaB was observed. Intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin exhibited a sustained increase in protein expression with time. The mRNA levels of these molecules were transiently upregulated and this was followed by a decrease in expression to levels lower than static controls. Regionally, increased inflammatory marker expression was observed in regions of WSS gradients both proximal and distal to the stenosis when compared with the uniform flow regions, whereas the atheroprotective markers were expressed to a greater extent in regions of elevated WSS magnitudes. The results from the straight/tubular model cannot explain the regional variation seen in the stenosis models. This may help explain the localization of inflammatory cells at the shoulders of plaques in vivo." @default.
• W2001280255 created "2016-06-24" @default.
• W2001280255 creator A5003671277 @default.
• W2001280255 creator A5045117406 @default.
• W2001280255 creator A5088260531 @default.
• W2001280255 date "2010-06-04" @default.
• W2001280255 modified "2023-10-15" @default.
• W2001280255 title "The Response of Human Aortic Endothelial Cells in a Stenotic Hemodynamic Environment: Effect of Duration, Magnitude, and Spatial Gradients in Wall Shear Stress" @default.
• W2001280255 cites W1839057479 @default.
• W2001280255 cites W1903574773 @default.
• W2001280255 cites W1963985214 @default.
• W2001280255 cites W1965772617 @default.
• W2001280255 cites W1967866136 @default.
• W2001280255 cites W1969706956 @default.
• W2001280255 cites W1982890949 @default.
• W2001280255 cites W1988540261 @default.
• W2001280255 cites W1991867763 @default.
• W2001280255 cites W2001284841 @default.
• W2001280255 cites W2008961036 @default.
• W2001280255 cites W2009521038 @default.
• W2001280255 cites W2010866783 @default.
• W2001280255 cites W2014108310 @default.
• W2001280255 cites W2016112964 @default.
• W2001280255 cites W2020300251 @default.
• W2001280255 cites W2020331803 @default.
• W2001280255 cites W2023359747 @default.
• W2001280255 cites W2027339613 @default.
• W2001280255 cites W2027979559 @default.
• W2001280255 cites W2034211557 @default.
• W2001280255 cites W2038542977 @default.
• W2001280255 cites W2043609441 @default.
• W2001280255 cites W2046950982 @default.
• W2001280255 cites W2047362606 @default.
• W2001280255 cites W2050982071 @default.
• W2001280255 cites W2051290526 @default.
• W2001280255 cites W2052364512 @default.
• W2001280255 cites W2053320203 @default.
• W2001280255 cites W2054312358 @default.
• W2001280255 cites W2056458634 @default.
• W2001280255 cites W2061382541 @default.
• W2001280255 cites W2064711537 @default.
• W2001280255 cites W2065591461 @default.
• W2001280255 cites W2069297972 @default.
• W2001280255 cites W2070323211 @default.
• W2001280255 cites W2071404882 @default.
• W2001280255 cites W2074499846 @default.
• W2001280255 cites W2079588435 @default.
• W2001280255 cites W2082593218 @default.
• W2001280255 cites W2083217753 @default.
• W2001280255 cites W2083396457 @default.
• W2001280255 cites W2090963427 @default.
• W2001280255 cites W2097103756 @default.
• W2001280255 cites W2097818208 @default.
• W2001280255 cites W2099167181 @default.
• W2001280255 cites W2100031693 @default.
• W2001280255 cites W2100124039 @default.
• W2001280255 cites W2101770878 @default.
• W2001280255 cites W2109478329 @default.
• W2001280255 cites W2111076607 @default.
• W2001280255 cites W2113357422 @default.
• W2001280255 cites W2114704077 @default.
• W2001280255 cites W2120058838 @default.
• W2001280255 cites W2120871101 @default.
• W2001280255 cites W2122450058 @default.
• W2001280255 cites W2125088273 @default.
• W2001280255 cites W2125521195 @default.
• W2001280255 cites W2125764762 @default.
• W2001280255 cites W2127306451 @default.
• W2001280255 cites W2127309246 @default.
• W2001280255 cites W2128177783 @default.
• W2001280255 cites W2133546870 @default.
• W2001280255 cites W2134688511 @default.
• W2001280255 cites W2135531568 @default.
• W2001280255 cites W2139319526 @default.
• W2001280255 cites W2143988452 @default.
• W2001280255 cites W2147367812 @default.
• W2001280255 cites W2147919276 @default.
• W2001280255 cites W2153774317 @default.
• W2001280255 cites W2155516654 @default.
• W2001280255 cites W2155939240 @default.
• W2001280255 cites W2160152518 @default.
• W2001280255 cites W2166173246 @default.
• W2001280255 cites W2166251000 @default.
• W2001280255 cites W2166445799 @default.
• W2001280255 cites W2166581295 @default.
• W2001280255 cites W2166646911 @default.
• W2001280255 cites W2168856219 @default.
• W2001280255 cites W2171825668 @default.
• W2001280255 cites W2177270915 @default.
• W2001280255 cites W2185483792 @default.
• W2001280255 cites W2262423141 @default.
• W2001280255 cites W2305619112 @default.
• W2001280255 cites W2310033666 @default.
• W2001280255 cites W234396583 @default.
• W2001280255 cites W2440099833 @default.
• W2001280255 cites W38820023 @default.
• W2001280255 cites W4232857156 @default.
• W2001280255 doi "https://doi.org/10.1115/1.4001217" @default.
• W2001280255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20590293" @default.
• W2001280255 hasPublicationYear "2010" @default.

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