FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001281077> ?p ?o ?g. }

• W2001281077 endingPage "C1187" @default.
• W2001281077 startingPage "C1178" @default.
• W2001281077 abstract "Recent studies suggest that the rapid and nongenomic effects of estradiol may be mediated through the G protein-coupled receptor dubbed GPR30 receptor. The present study examines the role of GPR30 versus a classical estrogen receptor (ERα) in mediating the growth regulatory effects of estradiol. GPR30 is readily detectable in freshly isolated vascular tissue but barely detectable in cultured vascular smooth muscle cells (VSMC). In freshly isolated aortic tissue, estradiol stimulated extracellular signal-regulated kinases (ERK) phosphorylation. In contrast, in cultured VSMC, where GPR30 expression is significantly reduced, estradiol inhibits ERK phosphorylation. Transfer of the genes encoding GPR30 led to estradiol stimulation of ERK phosphorylation, which is opposite the effects of estradiol in the primary culture of VSMCs. Transduction of the mineralocorticoid receptor (MR) had no effect on estradiol effects on ERK. Estradiol-mediated stimulation of ERK subsequent to heterologous GPR30 expression was pertussis toxin sensitive and phosphoinositide 3-kinase (PI3 kinase) dependent; under these conditions, estradiol also inhibited protein kinase A (PKA). In contrast, in the absence of GPR30 expression in cultured VSMC, estradiol stimulated PKA activity and inhibited ERK phosphorylation. To determine the functional effect of GPR30 (vs. estrogen receptor expression), we assessed estradiol-mediated apoptosis. In the absence of GPR30 expression, estradiol inhibited apoptosis. This effect was enhanced with ERα expression. In contrast, with GPR30 expression, estradiol stimulated apoptosis in an ERK-dependent manner. Thus the effect of estradiol on vascular smooth muscle cell apoptosis is likely dependent on the balance between ER-mediated PKA activation and GPR30-mediated PKA inhibition and PI3 kinase activation. Taken together, we postulate that modulation of GPR30 expression or activity may be an important determinant of the effects of estradiol in the vasculature." @default.
• W2001281077 created "2016-06-24" @default.
• W2001281077 creator A5007560814 @default.
• W2001281077 creator A5072621917 @default.
• W2001281077 creator A5086900416 @default.
• W2001281077 creator A5090719615 @default.
• W2001281077 creator A5091025989 @default.
• W2001281077 date "2009-11-01" @default.
• W2001281077 modified "2023-10-14" @default.
• W2001281077 title "Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30" @default.
• W2001281077 cites W1967479320 @default.
• W2001281077 cites W1971784720 @default.
• W2001281077 cites W1972086601 @default.
• W2001281077 cites W1972520826 @default.
• W2001281077 cites W1972977873 @default.
• W2001281077 cites W1981467972 @default.
• W2001281077 cites W1985405058 @default.
• W2001281077 cites W1989069744 @default.
• W2001281077 cites W1995829325 @default.
• W2001281077 cites W1996732665 @default.
• W2001281077 cites W2001500298 @default.
• W2001281077 cites W2015497140 @default.
• W2001281077 cites W2015692999 @default.
• W2001281077 cites W2022072580 @default.
• W2001281077 cites W2038885011 @default.
• W2001281077 cites W2041329755 @default.
• W2001281077 cites W2054519659 @default.
• W2001281077 cites W2055135135 @default.
• W2001281077 cites W2065785294 @default.
• W2001281077 cites W2080369709 @default.
• W2001281077 cites W2080987913 @default.
• W2001281077 cites W2095126097 @default.
• W2001281077 cites W2095823516 @default.
• W2001281077 cites W2116832131 @default.
• W2001281077 cites W2119051526 @default.
• W2001281077 cites W2122015809 @default.
• W2001281077 cites W2136324267 @default.
• W2001281077 cites W2143176261 @default.
• W2001281077 cites W2146936132 @default.
• W2001281077 cites W2149713530 @default.
• W2001281077 cites W2151262466 @default.
• W2001281077 cites W2151791648 @default.
• W2001281077 cites W2153285246 @default.
• W2001281077 cites W2160118258 @default.
• W2001281077 cites W2160270310 @default.
• W2001281077 cites W2160861480 @default.
• W2001281077 cites W2161185871 @default.
• W2001281077 cites W2166448577 @default.
• W2001281077 cites W238405157 @default.
• W2001281077 cites W2410292480 @default.
• W2001281077 doi "https://doi.org/10.1152/ajpcell.00185.2009" @default.
• W2001281077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19741198" @default.
• W2001281077 hasPublicationYear "2009" @default.
• W2001281077 type Work @default.
• W2001281077 sameAs 2001281077 @default.
• W2001281077 citedByCount "97" @default.
• W2001281077 countsByYear W20012810772012 @default.
• W2001281077 countsByYear W20012810772013 @default.
• W2001281077 countsByYear W20012810772014 @default.
• W2001281077 countsByYear W20012810772015 @default.
• W2001281077 countsByYear W20012810772016 @default.
• W2001281077 countsByYear W20012810772017 @default.
• W2001281077 countsByYear W20012810772018 @default.
• W2001281077 countsByYear W20012810772019 @default.
• W2001281077 countsByYear W20012810772020 @default.
• W2001281077 countsByYear W20012810772021 @default.
• W2001281077 countsByYear W20012810772022 @default.
• W2001281077 countsByYear W20012810772023 @default.
• W2001281077 crossrefType "journal-article" @default.
• W2001281077 hasAuthorship W2001281077A5007560814 @default.
• W2001281077 hasAuthorship W2001281077A5072621917 @default.
• W2001281077 hasAuthorship W2001281077A5086900416 @default.
• W2001281077 hasAuthorship W2001281077A5090719615 @default.
• W2001281077 hasAuthorship W2001281077A5091025989 @default.
• W2001281077 hasConcept C11960822 @default.
• W2001281077 hasConcept C121608353 @default.
• W2001281077 hasConcept C126322002 @default.
• W2001281077 hasConcept C134018914 @default.
• W2001281077 hasConcept C166471694 @default.
• W2001281077 hasConcept C184235292 @default.
• W2001281077 hasConcept C185592680 @default.
• W2001281077 hasConcept C2779395532 @default.
• W2001281077 hasConcept C2992686903 @default.
• W2001281077 hasConcept C530470458 @default.
• W2001281077 hasConcept C57074206 @default.
• W2001281077 hasConcept C62478195 @default.
• W2001281077 hasConcept C71924100 @default.
• W2001281077 hasConcept C84606932 @default.
• W2001281077 hasConcept C86803240 @default.
• W2001281077 hasConcept C95444343 @default.
• W2001281077 hasConceptScore W2001281077C11960822 @default.
• W2001281077 hasConceptScore W2001281077C121608353 @default.
• W2001281077 hasConceptScore W2001281077C126322002 @default.
• W2001281077 hasConceptScore W2001281077C134018914 @default.
• W2001281077 hasConceptScore W2001281077C166471694 @default.
• W2001281077 hasConceptScore W2001281077C184235292 @default.
• W2001281077 hasConceptScore W2001281077C185592680 @default.
• W2001281077 hasConceptScore W2001281077C2779395532 @default.

• next