FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001282249> ?p ?o ?g. }

• W2001282249 endingPage "498" @default.
• W2001282249 startingPage "488" @default.
• W2001282249 abstract "The purpose of this study is to evaluate the osteoconductivity of three different bone substitute materials: α-tricalcium phosphate (α-TCP), (β-TCP), and hydroxyapatite (HA), combined with or without simvastatin, which is a cholesterol synthesis inhibitor stimulating BMP-2 expression in osteoblasts. We used 72 Wistar rats and prepared two calvarial bone defects of 5 mm diameter in each rat. Defects were filled with the particles of 500-750 μm diameter combined with or without simvastatin at 0.1 mg dose for each defect. In the control group, defects were left empty. Animals were divided into seven groups: α-TCP, β-TCP, HA, α-TCP with simvastatin, β-TCP with simvastatin, HA with simvastatin, and control. The animals were sacrificed at 6 and 8 weeks. The calvariae were dissected out and analyzed with micro CT. The specimens were evaluated histologically and histomorphometrically. In α-TCP group, the amount of newly formed bone was significantly more than both HA and control groups but not significantly yet more than β-TCP group. Degradation of α-TCP was prominent and β-TCP showed slower rate while HA showed the least degradation. Combining the materials with Simvastatin led to increasing in the amount of newly formed bone. These results confirmed that α-TCP, β-TCP, and HA are osteoconductive materials acting as space maintainer for bone formation and that combining these materials with simvastatin stimulates bone regeneration and it also affects degradability of α-TCP and β-TCP. Conclusively, α-TCP has the advantage of higher rate of degradation allowing the more bone formation and combining α-TCP with simvastatin enhances this property." @default.
• W2001282249 created "2016-06-24" @default.
• W2001282249 creator A5011025530 @default.
• W2001282249 creator A5021448305 @default.
• W2001282249 creator A5028964841 @default.
• W2001282249 creator A5058776872 @default.
• W2001282249 date "2011-06-16" @default.
• W2001282249 modified "2023-10-14" @default.
• W2001282249 title "Evaluation of the osteoconductivity of α-tricalcium phosphate, β-tricalcium phosphate, and hydroxyapatite combined with or without simvastatin in rat calvarial defect" @default.
• W2001282249 cites W1569967577 @default.
• W2001282249 cites W1965106162 @default.
• W2001282249 cites W1982317574 @default.
• W2001282249 cites W1989892587 @default.
• W2001282249 cites W1993154983 @default.
• W2001282249 cites W1996290582 @default.
• W2001282249 cites W1997329210 @default.
• W2001282249 cites W2008831228 @default.
• W2001282249 cites W2011350479 @default.
• W2001282249 cites W2013061235 @default.
• W2001282249 cites W2020364703 @default.
• W2001282249 cites W2030748676 @default.
• W2001282249 cites W2034803983 @default.
• W2001282249 cites W2038150040 @default.
• W2001282249 cites W2041091867 @default.
• W2001282249 cites W2046278233 @default.
• W2001282249 cites W2047971760 @default.
• W2001282249 cites W2048433880 @default.
• W2001282249 cites W2054465891 @default.
• W2001282249 cites W2055923991 @default.
• W2001282249 cites W2078009047 @default.
• W2001282249 cites W2097850892 @default.
• W2001282249 cites W2098246513 @default.
• W2001282249 cites W2112714135 @default.
• W2001282249 cites W2132131875 @default.
• W2001282249 cites W2166650033 @default.
• W2001282249 cites W2167912395 @default.
• W2001282249 cites W2414146254 @default.
• W2001282249 cites W34123569 @default.
• W2001282249 doi "https://doi.org/10.1002/jbm.a.33117" @default.
• W2001282249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21681941" @default.
• W2001282249 hasPublicationYear "2011" @default.
• W2001282249 type Work @default.
• W2001282249 sameAs 2001282249 @default.
• W2001282249 citedByCount "101" @default.
• W2001282249 countsByYear W20012822492012 @default.
• W2001282249 countsByYear W20012822492013 @default.
• W2001282249 countsByYear W20012822492014 @default.
• W2001282249 countsByYear W20012822492015 @default.
• W2001282249 countsByYear W20012822492016 @default.
• W2001282249 countsByYear W20012822492017 @default.
• W2001282249 countsByYear W20012822492018 @default.
• W2001282249 countsByYear W20012822492019 @default.
• W2001282249 countsByYear W20012822492020 @default.
• W2001282249 countsByYear W20012822492021 @default.
• W2001282249 countsByYear W20012822492022 @default.
• W2001282249 countsByYear W20012822492023 @default.
• W2001282249 crossrefType "journal-article" @default.
• W2001282249 hasAuthorship W2001282249A5011025530 @default.
• W2001282249 hasAuthorship W2001282249A5021448305 @default.
• W2001282249 hasAuthorship W2001282249A5028964841 @default.
• W2001282249 hasAuthorship W2001282249A5058776872 @default.
• W2001282249 hasConcept C126322002 @default.
• W2001282249 hasConcept C136229726 @default.
• W2001282249 hasConcept C192562407 @default.
• W2001282249 hasConcept C2776329913 @default.
• W2001282249 hasConcept C2993291840 @default.
• W2001282249 hasConcept C71924100 @default.
• W2001282249 hasConcept C98274493 @default.
• W2001282249 hasConceptScore W2001282249C126322002 @default.
• W2001282249 hasConceptScore W2001282249C136229726 @default.
• W2001282249 hasConceptScore W2001282249C192562407 @default.
• W2001282249 hasConceptScore W2001282249C2776329913 @default.
• W2001282249 hasConceptScore W2001282249C2993291840 @default.
• W2001282249 hasConceptScore W2001282249C71924100 @default.
• W2001282249 hasConceptScore W2001282249C98274493 @default.
• W2001282249 hasIssue "4" @default.
• W2001282249 hasLocation W20012822491 @default.
• W2001282249 hasLocation W20012822492 @default.
• W2001282249 hasOpenAccess W2001282249 @default.
• W2001282249 hasPrimaryLocation W20012822491 @default.
• W2001282249 hasRelatedWork W1980516119 @default.
• W2001282249 hasRelatedWork W2044626967 @default.
• W2001282249 hasRelatedWork W2294718481 @default.
• W2001282249 hasRelatedWork W2348937697 @default.
• W2001282249 hasRelatedWork W2349278956 @default.
• W2001282249 hasRelatedWork W2378470583 @default.
• W2001282249 hasRelatedWork W2378888842 @default.
• W2001282249 hasRelatedWork W2385465383 @default.
• W2001282249 hasRelatedWork W2779684547 @default.
• W2001282249 hasRelatedWork W3121575904 @default.
• W2001282249 hasVolume "98A" @default.
• W2001282249 isParatext "false" @default.
• W2001282249 isRetracted "false" @default.
• W2001282249 magId "2001282249" @default.
• W2001282249 workType "article" @default.