Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001286676> ?p ?o ?g. }
- W2001286676 endingPage "30" @default.
- W2001286676 startingPage "24" @default.
- W2001286676 abstract "Estrogen receptor alpha (ERα) mediates estrogen (E2) actions in the brain and is critical for normal reproductive function and behavior. In the classical pathway, ERα binds to estrogen response elements (EREs) to regulate gene transcription. ERα can also participate in several non-classical pathways, including ERE-independent gene transcription via protein–protein interactions with transcription factors and rapid, non-genotropic pathways. To distinguish between ERE-dependent and ERE-independent mechanisms of E2 action in vivo, we have created ERα null mice that possess an ER knock-in mutation (E207A/G208A; “AA”), in which the mutant ERα cannot bind to DNA but retains activity in ERE-independent pathways (ERα−/AA mice). Understanding the molecular mechanisms of ERα action will be helpful in developing pharmacological therapies that differentiate between ERE-dependent and ERE-independent processes. This review focuses on how the ERα−/AA model has contributed to our knowledge of ERα signaling mechanisms in estrogen regulation of the reproductive axis and sexual behavior." @default.
- W2001286676 created "2016-06-24" @default.
- W2001286676 creator A5003540215 @default.
- W2001286676 creator A5004381815 @default.
- W2001286676 creator A5014769599 @default.
- W2001286676 creator A5014827661 @default.
- W2001286676 creator A5063849935 @default.
- W2001286676 creator A5080929355 @default.
- W2001286676 creator A5090955809 @default.
- W2001286676 date "2008-08-01" @default.
- W2001286676 modified "2023-10-17" @default.
- W2001286676 title "New insights into the classical and non-classical actions of estrogen: Evidence from estrogen receptor knock-out and knock-in mice" @default.
- W2001286676 cites W1549100704 @default.
- W2001286676 cites W1591317354 @default.
- W2001286676 cites W1736447480 @default.
- W2001286676 cites W1965007233 @default.
- W2001286676 cites W1968104734 @default.
- W2001286676 cites W1978761842 @default.
- W2001286676 cites W1989347905 @default.
- W2001286676 cites W1993005991 @default.
- W2001286676 cites W1996197907 @default.
- W2001286676 cites W1996477279 @default.
- W2001286676 cites W2006727096 @default.
- W2001286676 cites W2017989931 @default.
- W2001286676 cites W2019914463 @default.
- W2001286676 cites W2024364396 @default.
- W2001286676 cites W2026163871 @default.
- W2001286676 cites W2031326939 @default.
- W2001286676 cites W2039871782 @default.
- W2001286676 cites W2045590624 @default.
- W2001286676 cites W2051684862 @default.
- W2001286676 cites W2052104297 @default.
- W2001286676 cites W2052306492 @default.
- W2001286676 cites W2058382270 @default.
- W2001286676 cites W2067767450 @default.
- W2001286676 cites W2074746487 @default.
- W2001286676 cites W2076127338 @default.
- W2001286676 cites W2078862855 @default.
- W2001286676 cites W2081501399 @default.
- W2001286676 cites W2085951921 @default.
- W2001286676 cites W2088522077 @default.
- W2001286676 cites W2093350076 @default.
- W2001286676 cites W2097004442 @default.
- W2001286676 cites W2104854481 @default.
- W2001286676 cites W2111072866 @default.
- W2001286676 cites W2114220190 @default.
- W2001286676 cites W2115699651 @default.
- W2001286676 cites W2120653485 @default.
- W2001286676 cites W2120809075 @default.
- W2001286676 cites W2123701647 @default.
- W2001286676 cites W2128840922 @default.
- W2001286676 cites W2129115045 @default.
- W2001286676 cites W2136248304 @default.
- W2001286676 cites W2140440723 @default.
- W2001286676 cites W2141269411 @default.
- W2001286676 cites W2155707999 @default.
- W2001286676 cites W2159744955 @default.
- W2001286676 cites W2169670549 @default.
- W2001286676 cites W2172256092 @default.
- W2001286676 cites W4230612782 @default.
- W2001286676 cites W4233294018 @default.
- W2001286676 cites W4233816418 @default.
- W2001286676 cites W4241870034 @default.
- W2001286676 cites W4243750598 @default.
- W2001286676 cites W4245385034 @default.
- W2001286676 cites W4248453414 @default.
- W2001286676 cites W4249012312 @default.
- W2001286676 cites W4253785546 @default.
- W2001286676 cites W4254601021 @default.
- W2001286676 cites W4254658215 @default.
- W2001286676 cites W4255377732 @default.
- W2001286676 doi "https://doi.org/10.1016/j.mce.2008.04.003" @default.
- W2001286676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2562461" @default.
- W2001286676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18534740" @default.
- W2001286676 hasPublicationYear "2008" @default.
- W2001286676 type Work @default.
- W2001286676 sameAs 2001286676 @default.
- W2001286676 citedByCount "128" @default.
- W2001286676 countsByYear W20012866762012 @default.
- W2001286676 countsByYear W20012866762013 @default.
- W2001286676 countsByYear W20012866762014 @default.
- W2001286676 countsByYear W20012866762015 @default.
- W2001286676 countsByYear W20012866762016 @default.
- W2001286676 countsByYear W20012866762017 @default.
- W2001286676 countsByYear W20012866762018 @default.
- W2001286676 countsByYear W20012866762019 @default.
- W2001286676 countsByYear W20012866762020 @default.
- W2001286676 countsByYear W20012866762021 @default.
- W2001286676 countsByYear W20012866762022 @default.
- W2001286676 countsByYear W20012866762023 @default.
- W2001286676 crossrefType "journal-article" @default.
- W2001286676 hasAuthorship W2001286676A5003540215 @default.
- W2001286676 hasAuthorship W2001286676A5004381815 @default.
- W2001286676 hasAuthorship W2001286676A5014769599 @default.
- W2001286676 hasAuthorship W2001286676A5014827661 @default.
- W2001286676 hasAuthorship W2001286676A5063849935 @default.
- W2001286676 hasAuthorship W2001286676A5080929355 @default.
- W2001286676 hasAuthorship W2001286676A5090955809 @default.