FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001290314> ?p ?o ?g. }

• W2001290314 endingPage "1193" @default.
• W2001290314 startingPage "1187" @default.
• W2001290314 abstract "Background & AimsGuidelines recommend that patients with symptoms of nonconstipated irritable bowel syndrome (NC-IBS) undergo testing for celiac disease (CD). We evaluated the prevalence of CD antibodies, and biopsy confirmed CD among patients with NC-IBS in a large US population.MethodsIn a study conducted at 4 sites, from 2003 to 2008, we compared data from 492 patients with symptoms of NC-IBS to 458 asymptomatic individuals who underwent colonoscopy examinations for cancer screening or polyp surveillance (controls). All participants provided blood samples for specific and nonspecific CD-associated antibodies. Additionally, patients with IBS were analyzed for complete blood cell counts, metabolic factors, erythrocyte sedimentation rates, and levels of C-reactive protein and thyroid-stimulating hormone. Any subjects found to have CD-associated antibodies were offered esophagogastroduodenoscopy and duodenal biopsy analysis.ResultsOf patients with NC-IBS, 7.3% had abnormal results for CD-associated antibodies, compared with 4.8% of controls (adjusted odds ratio, 1.49; 95% confidence interval: 0.76–2.90; P = .25). Within the NC-IBS group, 6.51% had antibodies against gliadin, 1.22% against tissue transglutaminase, and 0.61% against endomysium (P > .05 vs controls for all antibodies tested). CD was confirmed in 0.41% of patients in the NC-IBS group and 0.44% of controls (P > .99).ConclusionsAlthough CD-associated antibodies are relatively common, the prevalence of CD among patients with NC-IBS is similar to that among controls in a large US population. These findings challenge recommendations to routinely screen patients with NC-IBS for CD. More than 7% of patients with NC-IBS had CD-associated antibodies, suggesting that gluten sensitivity might mediate IBS symptoms; further studies are needed. Guidelines recommend that patients with symptoms of nonconstipated irritable bowel syndrome (NC-IBS) undergo testing for celiac disease (CD). We evaluated the prevalence of CD antibodies, and biopsy confirmed CD among patients with NC-IBS in a large US population. In a study conducted at 4 sites, from 2003 to 2008, we compared data from 492 patients with symptoms of NC-IBS to 458 asymptomatic individuals who underwent colonoscopy examinations for cancer screening or polyp surveillance (controls). All participants provided blood samples for specific and nonspecific CD-associated antibodies. Additionally, patients with IBS were analyzed for complete blood cell counts, metabolic factors, erythrocyte sedimentation rates, and levels of C-reactive protein and thyroid-stimulating hormone. Any subjects found to have CD-associated antibodies were offered esophagogastroduodenoscopy and duodenal biopsy analysis. Of patients with NC-IBS, 7.3% had abnormal results for CD-associated antibodies, compared with 4.8% of controls (adjusted odds ratio, 1.49; 95% confidence interval: 0.76–2.90; P = .25). Within the NC-IBS group, 6.51% had antibodies against gliadin, 1.22% against tissue transglutaminase, and 0.61% against endomysium (P > .05 vs controls for all antibodies tested). CD was confirmed in 0.41% of patients in the NC-IBS group and 0.44% of controls (P > .99). Although CD-associated antibodies are relatively common, the prevalence of CD among patients with NC-IBS is similar to that among controls in a large US population. These findings challenge recommendations to routinely screen patients with NC-IBS for CD. More than 7% of patients with NC-IBS had CD-associated antibodies, suggesting that gluten sensitivity might mediate IBS symptoms; further studies are needed." @default.
• W2001290314 created "2016-06-24" @default.
• W2001290314 creator A5009695585 @default.
• W2001290314 creator A5010484696 @default.
• W2001290314 creator A5024380717 @default.
• W2001290314 creator A5027136649 @default.
• W2001290314 creator A5033336037 @default.
• W2001290314 creator A5043783243 @default.
• W2001290314 creator A5045004840 @default.
• W2001290314 creator A5068822894 @default.
• W2001290314 creator A5084221679 @default.
• W2001290314 date "2011-10-01" @default.
• W2001290314 modified "2023-09-25" @default.
• W2001290314 title "The Prevalence of Celiac Disease Among Patients With Nonconstipated Irritable Bowel Syndrome Is Similar to Controls" @default.
• W2001290314 cites W1965007454 @default.
• W2001290314 cites W1970096002 @default.
• W2001290314 cites W1970777571 @default.
• W2001290314 cites W1984140056 @default.
• W2001290314 cites W1985728328 @default.
• W2001290314 cites W1996626151 @default.
• W2001290314 cites W2000774337 @default.
• W2001290314 cites W2001357405 @default.
• W2001290314 cites W2003016949 @default.
• W2001290314 cites W2004646273 @default.
• W2001290314 cites W2012505724 @default.
• W2001290314 cites W2014330602 @default.
• W2001290314 cites W2025379515 @default.
• W2001290314 cites W2034857057 @default.
• W2001290314 cites W2050973834 @default.
• W2001290314 cites W2053761581 @default.
• W2001290314 cites W2064201279 @default.
• W2001290314 cites W2064403001 @default.
• W2001290314 cites W2065019547 @default.
• W2001290314 cites W2066647807 @default.
• W2001290314 cites W2066932270 @default.
• W2001290314 cites W2069634861 @default.
• W2001290314 cites W2078462317 @default.
• W2001290314 cites W2078685970 @default.
• W2001290314 cites W2094826830 @default.
• W2001290314 cites W2105445407 @default.
• W2001290314 cites W2107795135 @default.
• W2001290314 cites W2108727240 @default.
• W2001290314 cites W2113125357 @default.
• W2001290314 cites W2118346544 @default.
• W2001290314 cites W2119425622 @default.
• W2001290314 cites W2130505088 @default.
• W2001290314 cites W2131353417 @default.
• W2001290314 cites W2143731968 @default.
• W2001290314 cites W2154856571 @default.
• W2001290314 cites W2157300680 @default.
• W2001290314 cites W2616564376 @default.
• W2001290314 cites W4241288015 @default.
• W2001290314 cites W4247564530 @default.
• W2001290314 doi "https://doi.org/10.1053/j.gastro.2011.06.084" @default.
• W2001290314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3186819" @default.
• W2001290314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21762658" @default.
• W2001290314 hasPublicationYear "2011" @default.
• W2001290314 type Work @default.
• W2001290314 sameAs 2001290314 @default.
• W2001290314 citedByCount "111" @default.
• W2001290314 countsByYear W20012903142012 @default.
• W2001290314 countsByYear W20012903142013 @default.
• W2001290314 countsByYear W20012903142014 @default.
• W2001290314 countsByYear W20012903142015 @default.
• W2001290314 countsByYear W20012903142016 @default.
• W2001290314 countsByYear W20012903142017 @default.
• W2001290314 countsByYear W20012903142018 @default.
• W2001290314 countsByYear W20012903142019 @default.
• W2001290314 countsByYear W20012903142020 @default.
• W2001290314 countsByYear W20012903142021 @default.
• W2001290314 countsByYear W20012903142022 @default.
• W2001290314 countsByYear W20012903142023 @default.
• W2001290314 crossrefType "journal-article" @default.
• W2001290314 hasAuthorship W2001290314A5009695585 @default.
• W2001290314 hasAuthorship W2001290314A5010484696 @default.
• W2001290314 hasAuthorship W2001290314A5024380717 @default.
• W2001290314 hasAuthorship W2001290314A5027136649 @default.
• W2001290314 hasAuthorship W2001290314A5033336037 @default.
• W2001290314 hasAuthorship W2001290314A5043783243 @default.
• W2001290314 hasAuthorship W2001290314A5045004840 @default.
• W2001290314 hasAuthorship W2001290314A5068822894 @default.
• W2001290314 hasAuthorship W2001290314A5084221679 @default.
• W2001290314 hasBestOaLocation W20012903141 @default.
• W2001290314 hasConcept C121608353 @default.
• W2001290314 hasConcept C126322002 @default.
• W2001290314 hasConcept C156957248 @default.
• W2001290314 hasConcept C159654299 @default.
• W2001290314 hasConcept C203014093 @default.
• W2001290314 hasConcept C2775934546 @default.
• W2001290314 hasConcept C2777910003 @default.
• W2001290314 hasConcept C2778143017 @default.
• W2001290314 hasConcept C2778271842 @default.
• W2001290314 hasConcept C2778435480 @default.
• W2001290314 hasConcept C2778451229 @default.
• W2001290314 hasConcept C2779134260 @default.
• W2001290314 hasConcept C2780349322 @default.
• W2001290314 hasConcept C2780717491 @default.
• W2001290314 hasConcept C2781143854 @default.

• next